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Table 1 Co-distribution of PQSs with variant-antigen-encoding gene families in Plasmodium spp.

From: Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs

Plasmodium spp.

No. genes in gene family

Mean distance from a PQS (kb)

Mean distance from a PQS in null dataset (kb)

Difference between actual & null data (kb)

Co-distribution (p-values)

P. falciparum

61

101.8

324.2

222.4

Y (p < 0.001)

P. berghei

217

356.3

414.2

57.9

Y (p = 0.021)

  1. The distribution of distances between var or pir genes and their nearest PQS was compared to the distribution of distances in a simulated genome containing randomly-located genes. Differences between the actual and null datasets were assessed by Welch’s t-test (2-tailed)
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BMC Genomics

ISSN: 1471-2164

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