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Table 2 Characteristics of putative G-quadruplex-forming sequences in the P. falciparum 3D7 genome

From: Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs

PQS group Total # PQSs in group # PQSs with total loop length ≤7 # of 1 or 2 nucleotide loops # single pyrimidine (not purine) loops # PQSs with a longest-central loop
1 nt 2 nt
Var-associated 35 2 (5.7 %) 4 (3.8 %) 4 (3.8 %) 4 (3.8 %) 23 (65.7 %)
Non-var-associated 45 13 (28.9 %) 23 (17.0 %) 18 (13.3 %) 2 (1.5 %) 9 (20 %)
Total 80 15 (18.8 %) 27 (11.3 %) 22 (9.2 %) 6 (2.5 %) 32 (40 %)
Signif. difference?   Y Y N Y
p-value   0.0095 <0.0001 0.3959 <0.0001
  1. Var-associated and non-var-associated groups of PQSs were scored for the four characteristics predicted to be G4-stabilizing: the table shows the number of PQSs in each group showing each characteristic. Differences between the scores for the two groups were assessed by Fisher’s exact test (2-tailed)