Skip to main content

Table 4 Locations of PQS in the genomes of P. falciparum, P. reichenowi and P. berghei

From: Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs

   Genome  
P. falciparum 3D7 P. reichenowi CDC P. berghei ANKA
All PQS    
 Within a gene 34 40 11
 Upstream (within 2 kb) 37 5 30
 Downstream (within 2 kb) 7 8 7
 No gene within 2 kb 2 0 0
 Total 80 53 48
Var-associated PQS
 Within a var gene 19 33 (inc. 1 pseudogene)  
 Upstream (within 2 kb) 16 0  
 Downstream (within 2 kb) 0 0  
 Total var sequences 103a 103a  
Var genes 63a 64a  
 Fragments/pseudogenes 6/34a 37/22a  
Pir-associated PQS
 Within a pir gene 3 0 0
 Upstream (within 2 kb) 0 1 28
 Downstream (within 2 kb) 0 1 6
 Total pir sequences 226a 528a 299
Pir genes 189a 351a 217
 Fragments/pseudogenes 0/37a 118/59a 0/82
  1. Table shows numbers of PQS found in each Plasmodium genome analysed. ‘Fragments/pseudogenes’ refers to the numbers of incomplete, but recognizable, var gene sequences, which are designated as gene fragments or pseudogenes
  2. aIndicates gene numbers taken from Otto et al. [31]