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Table 4 Top 10 GO Term and Broad MSigDB Canonical Pathway enrichments for 2 most correlated modules in PPvPT

From: Network analysis of psoriasis reveals biological pathways and roles for coding and long non-coding RNAs

Module

GO Term

pGO

Broad MSigDB Canonical Pathway

pBroad

Sienna3

regulation of leukocyte mediated cytotoxicity

1.40E-05

Genes involved in Lipid digestion, mobilization, and transport

1.70E-05

regulation of cell killing

1.90E-05

Antigen processing and presentation

0.0002

leukocyte activation

0.0001

Genes involved in Neuronal System

0.0004

T cell activation

0.0001

Genes involved in Lipoprotein metabolism

0.0004

monosaccharide metabolic process

0.0001

Genes involved in Glucose metabolism

0.0004

positive regulation of immune response

0.0002

Visual signal transduction: Cones

0.0005

cytokine production

0.0003

Signaling events mediated by HDAC Class II

0.0008

cell surface

0.0005

ABC transporters

0.0011

MHC protein binding

0.0005

Downstream signaling in CD8+ T cells

0.0015

microtubule organizing center

0.0006

Genes involved in Transmission across Chemical Synapses

0.0015

Lightyellow

protein complex disassembly

1.00E-10

Ribosome, cytoplasmic

2.10E-11

protein targeting to ER

1.10E-10

Ribosome

3.50E-11

establishment of protein localization to endoplasmic reticulum

1.10E-10

Genes involved in 3' -UTR-mediated translational regulation

6.90E-11

viral infectious cycle

2.20E-10

Genes involved in Translation

3.70E-10

macromolecular complex disassembly

3.10E-10

Genes involved in Peptide chain elongation

7.30E-10

ribosomal subunit

4.50E-10

Genes involved in Influenza Viral RNA Transcription and Replication

1.40E-09

cytosolic part

3.50E-09

Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex

1.70E-09

establishment of protein localization to organelle

5.70E-09

Genes involved in SRP-dependent cotranslational protein targeting to membrane

1.90E-09

cellular component disassembly at cellular level

1.20E-08

Genes involved in Influenza Life Cycle

4.30E-09

cellular component disassembly

1.30E-08

Genes involved in Metabolism of proteins

5.30E-09