Skip to main content
Fig. 2 | BMC Genomics

Fig. 2

From: Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq

Fig. 2

Volcano Plot showing –log10(p-value) vs log2(normalized fold change (FC)) of RNA-seq FPKM (Fragments per kilobase of exon per million fragments mapped) for all transcripts (protein-coding and non-coding) differentially expressed genes (DEG) in kidney samples of Ins2 Akita mouse model of diabetic nephropathy. Distribution of genes with respect to significance (y axis) versus fold changes (x axis) is shown. Genes of interest outside the midline where absolute normalized FC > =+/-4 (q < 0.05) are labeled as examples to show changes in expression levels in diabetic (DvC, Red) or P78 treated diabetic mice (TvD, Green) relative to controls. Horizontal dashed line represents expression value p = 0.05; above line p < 0.05; below line: p > 0.05. Genes outside the midline have FC > 1

Back to article page