Fig. 7
From: Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq
Canonical pathways identified by Ingenuity pathway analysis (IPA) gene ontology algorithms for all significant and reliable DEG in the dataset. a. DvC: diabetic Ins2 Akita mouse kidney samples. b. TvD: kidney samples obtained from Ins2 Akita mice after 6 weeks of continuous P78 infusion. Canonical pathways are displayed along the x-axis and the –log(p-value), calculated by Fisher’s exact test right-tailed, on the y-axis. Threshold set to 1.5 indicates the minimum significance level (–log(p-value). Height of the bars represents significance (probability that DEG in the dataset are associated with a canonical pathway) with taller bars representing more significant associations. The ratio (orange points) indicates the number of DEG (FC > 1.5; q < 0.05) in the diabetes and treatment datasets that map to a given canonical pathway divided by the total number of genes in that pathway within the IPA reference list