Fig. 8
From: Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq
Regulation profile of genes in the canonical pathways most significantly associated with DEG in our RNAseq dataset. a. Diabetic Ins2 Akita kidney samples relative to control. b. P78-treated diabetic Ins2 Akita kidney samples relative to control. The stacked bars show the percentage of genes (y-axis) distributed according to the direction of gene regulation changes in each canonical pathway (x-axis). Genes that were significantly up-regulated in our dataset are shown in red, those that were down-regulated in green, and those found in the IPA reference gene set that had no overlap with our dataset represented as open bars. The numerical value at the right of each canonical pathway bar indicates the total number of genes present in the IPA Knowledge base for that pathway. The orange line represents the significance of the directional change (–log(p-value) calculated by adjusting the right-tailed Fisher’s Exact t-test p-values using the Benjamini-Hochberg method