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Fig. 4 | BMC Genomics

Fig. 4

From: Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology

Fig. 4

Chromosomal instability signature and micronuclei in AAE6 epithelia. a The CIN70 score relative to HPV-negative NIKS was significantly higher in AAE6 compared to EPE6 epithelia (2.32 fold higher, P = 0.02 by Welch’s T-test). Mean values are shown with error bars representing standard deviation (n = 3). Statistical significance (P < 0.05) denoted by “*”. b Haematoxylin and eosin micrographs of FFPE AAE6 epithelia, 400× cropped, micronuclei indicated by arrow. Close-up shows micronucleus and normal-sized nucleus within same cell

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BMC Genomics

ISSN: 1471-2164

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