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Table 3 Identification of potential RDs for lineage classification in Mtb lineages without existing RD markers

From: In silico region of difference (RD) analysis of Mycobacterium tuberculosis complex from sequence reads using RD-Analyzer

Lineage

Sample size

RD detected

Performance

No.

Start

End

Length (bp)

Sensitivity

Specificity

Lineage 4.3.4.2.1

15

1

164,942

165,740

799

100 % (15/15)

100 % (102/102)

Lineage 4.6.1.2

11

1

2,902,556

2,904,328

1,773

100 % (11/11)

97.17 % (103/106)

2

2,265,142

2,266,241

1,100

100 % (11/11)

98.11 % (104/106)

3

1,190,141

1,190,733

593

  

4

2,634,174

2,634,542

369

  

5

3,594,343

3,594,407

65

  

Lineage 4.6.2.2

4

1

1,897,554

1,900,204

2,651

100 % (4/4)

99.12 % (112/113)

2

3,785,220

3,785,638

419

  

3

3,905,337

3,905,721

385

  

4

3,742,614

3,742,895

282

  

Lineage 4.4.1.1

4

1

2,025,760

2,028,437

2,678

100 % (4/4)

99.12 % (112/113)

2

3,123,673

3,125,705

2,033

100 % (4/4)

99.12 % (112/113)

3

3,112,311

3,112,459

149

  

4

1,313,135

1,313,278

144

  

5

3,377,623

3,377,670

48

  
  1. Note Bold letters refer to the potential RD markers whose sensitivity and specificity for classification have been assessed. The start and end positions correspond to the genomic positions of Mtb H37Rv genome