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Table 1 Count of genes that are differentially expressed when comparing growth substrates predicted by several methods

From: Genome-wide gene expression and RNA half-life measurements allow predictions of regulation and metabolic behavior in Methanosarcina acetivorans

Genes

     

Comparison

edgeR

DESeq2

PoissonSeq

Consensusb

 

MeOH vs Acetate

621

341

400

201 (126d)

 

MeOH vs TMA

2839

258

2348

211 (112d)

 

TMA vs Acetate

2762

757

1955

645 (335d)

 

Methylotrophic vs

511

179

301

100

 

Acetotrophic

     

Operonsa

     

Comparison

DOOR2

Microbes Online

ProOpDB

Rockhopper

Consensusc

MeOH vs Acetate

205 (144)

183 (110)

189 (129)

207 (151)

157

MeOH vs TMA

202 (148)

198 (117)

211 (143)

212 (158)

163

TMA vs Acetate

662 (450)

701 (343)

667 (406)

655 (469)

571

Methylotrophic vs

112 (75)

97 (53)

91 (56)

112 (79)

76

Acetotrophic

     
  1. aIntersection of the sets of differentially expressed genes predicted by the three methods. bCount of differentially expressed genes that are associated with reactions in the metabolic model. cThe differential expression procedure applied to reads summed over putative operons of a specific dataset, where the number reported is total genes called as differentially expressed, while the number in parenthesis is the total number of operons called as differentially expressed. dIntersection of the sets of differentially expressed genes predicted to be in differentially expressed operons (because operon structures were not conserved across the methods)