Fig. 4

Differential expression analysis from the de-novo study of 15 microarrays. a Heatmap of distances measured as the number of differentially expressed genes between each cell type. Red scale accounts for up-regulated genes in the cell type labelled in the right panel; whilst green intensities represent down-regulated genes. The more intense the colour, the greater the distance between cell types involved. b Same as a, but HSPCs were removed to improve the visualisation of the differences between stromal cell types. c-d-e Tables presenting the number of differentially expressed genes per pair-wise comparison, indicating the up-regulated genes in each type (e.g. in d, BM-MSC versus PL-MSC: 346 genes UP in BM and 392 in PL). f Venn diagrams showing the number of genes that are up-regulated in each contrast against: AD-MSC (green), BM-MSC (red), PL-MSC (blue) and FIB (yellow)