Table 2 Functional enrichment analysis of DE genes obtained from the meta-analysis approach

cytoplasmic membrane-bounded vesicle

SEPT5, TGOLN2, SEC31A, FSTL3, ITSN1, C14ORF1, APP, BDNF, DAB2, PICALM, SCAMP1, BSG, MYO6, ACTN1, OPTN, SSPN, SPAG9, VEGFC, SERPINF1, RAB14, TRAPPC4, PDCD6IP, COPZ2, CAV2, RAB7A, PAM, COPZ1, ATP6V1B2, ITGB1, CALU, TIMP1, STX12, SLC30A5, TMED10, FN1, AP2M1, PLAT, P4HB, BECN1, GARS, WIPI1, DVL1, LAMP1, LAMP2, PPIB, YIPF3, YIPF5, HSP90AB1, COPA, CLTA, CLTB, SEC24A, RAB5B, AP2S1, HEXB, AP3S1, GJA1, PDIA6, PDIA4, CLTC, CANX, RABAC1, SLC1A5, COPB2, AP2B1, TPP1, MAPKAP1, GOPC, GOLGA5, ATP6V0D1, SEC24D, STX6, SEC23A, ADAM10, STX2, PIK3C2A, STXBP1, TMEM187, BGN, IGF2R, ARCN1, RAB5A, SORT1, CTSD, CTSB, COPG, COPE, GANAB, ANXA6, CD9, TMED2, CRISPLD2, TMEM33, CAMK2D, RAB11A, SNAP23, GPNMB, THBS1, EHD1, THBS2, EHD3, HSPA8, THBS3, PHLDA1, YWHAB, SPARC, TMEM168, ANXA2, NCSTN, SH3BP4, SCFD1, HSP90B1, LRP1, SMPD1

114

5.73

8.84E-07

establishment of vesicle localization

SEPT5, BBS4, COPA, MAP2K1, BBS7, COPZ1, WIPI1, COPB2, ARF1, PSEN1, ARCN1, TMED10, SNAP23, COPG, YKT6, COPE

16

0.80

1.72E-04

blood vessel development

RTN4, NRP1, HTATIP2, PGF, PRRX1, ANPEP, MMP2, CXCL12, CITED2, MAP3K7, AKT1, SHB, ATG5, CTGF, ANG, ROBO1, SEMA3C, RHOB, LOX, NR2F2, FGF2, CYR61, RECK, MYH9, SLIT2, THY1, VEGFC, BGN, HIF1A, NUS1, PSEN1, COL1A2, FOXC1, COL1A1, ACVR1, CAV1, TNFRSF12A, COL3A1, CDH2, TCF7L2, SEMA5A, PTK2, ITGAV, CHM, THBS1, PPAP2B, C1GALT1, RASA1, PLAT, EPAS1, MYO1E, TGFBR2, COL5A1, ANXA2, CDH13, GPI, LAMA4, PKNOX1, ENG, PLAU

60

3.02

5.06E-06

apoptosis

DLC1, TSPO, HRAS, MEF2A, SGMS1, ITSN1, MAGED1, SHB, CLPTM1L, APP, CDKN2A, RAD21, ATG5, UNC5B, GATA6, FAS, DAP, CUL1, CIB1, TWIST1, FADD, LIG4, BCAP31, PDCD6IP, NEK6, BLCAP, TNFRSF12A, RRAGA, BCL2L2, STK17A, RRAGC, PEA15, PRUNE2, DOCK1, TCTN3, ABR, TM2D1, LGALS1, SRA1, TRIO, FXR1, VDAC1, NCKAP1, BFAR, VCP, RABEP1, RTN4, HTATIP2, SGPP1, ZMAT3, BNIP3, GJA1, PAWR, DAXX, RTN3, AKT1, TNFRSF11B, DYNLL1, PAK2, BOK, GSN, BAG3, BAG2, RHOB, FGF2, MYC, MAGEH1, NDUFS1, DHCR24, LTBR, NOL3, ARHGEF12, CDK5, ECT2, ELMO2, ZDHHC16, EYA2, PSEN1, AVEN, PSME3, UBE2Z, ITM2B, GLRX2, TNFRSF1A, BCAP29, THBS1, PHLDA3, PHLDA2, ERCC2, PHLDA1, ACTC1, IL6, DNM1L, TMBIM6, UBE4B, YWHAB, BAD, STAT1, PLEKHF1, NCSTN, BNIP3L, SULF1, PERP

103

5.18

2.75E-03

cell migration

CTHRC1, JUB, NRP1, CXCL12, CTGF, ANG, ROBO1, SEMA3C, CAP1, NR2F2, FGF2, TWIST1, PRKCA, PTPRK, SATB2, ARID5B, EMX2, NRD1, MYH9, CDK5, SLIT2, VEGFC, HIF1A, TNS1, PSEN1, CFL1, SIX1, PDGFRB, FOXC1, LAMC1, ACVR1, CAV2, CCL2, NDN, FUT8, TNFRSF12A, ITGA11, KITLG, CDH2, ITGB1, VCAM1, PTK2, PAFAH1B1, PPAP2A, THBS1, PPAP2B, APC, FN1, PLAT, IL6, MET, COL5A1, CDH13, FYN, ITGA5, LRP6, APBB2, ENG, PLAU, MYH10

60

3.02

2.36E-04

regulation of leukocyte activation

LST1, HMGB3, BLM, STAT5A, IL18, SNCA, SPINK5, SART1, CD74, ADA, IL31RA, IL1B, MS4A2, IL2RG, INPP5D, HLA-DOA, TRAF6, LAG3, CD28, SYK, FCER1A, PTPRC, IL2RA, GIMAP5, IKZF1, FLT3, SLA2, CTLA4, STXBP2, IDO1, NFAM1, PRKCQ, CD38, CD83, CORO1A, CD86, TNFSF13B, LAX1, PRAM1, RIPK2, IRF4, VSIG4, SASH3

43

1.92

9.33E-04

hemopoiesis

LMO2, STAT5A, JAG2, TPD52, IL31RA, CDC42, SYK, RHOH, MB, EGR1, TTC7A, LYN, EOMES, NFAM1, DHRS2, CD40LG, AICDA, ADD2, CALCR, GPR183, BLM, KIT, ZBTB16, SOX6, TRIM10, CD74, ADA, TAL1, DOCK2, CHD7, RASGRP4, BCL2, BCL11A, TRAF6, CD28, PTPRC, GIMAP5, IKZF1, PLEK, EPB42, FLT3, HCLS1, HDAC5, HOXB4, RPL22, PLCG2, IRF8, IRF1, IRF4, SPTA1, CD79A, KLF1

52

2.33

6.28E-03

positive regulation of T cell activation

PTPRC, IL2RA, GIMAP5, IKZF1, BLM, STAT5A, IL18, ADA, CD74, SART1, CD83, PRKCQ, CORO1A, CD86, TNFSF13B, RIPK2, IL1B, IL2RG, TRAF6, SASH3, CD28, SYK

22

0.98

2.44E-02

extracellular matrix

EGFL6, LGALS1, MMP27, GRIA3, EMILIN2, MMP3, NTN1, MMP1, WNT2, FBLN2, FBLN5, F3, FBN2, MFAP4

14

7.57

5.22E-03

calcium ion binding

S100A4, F10, MASP1, LDLR, EGFL6, SCUBE2, MMP27, COLEC12, GALNTL1, MMP3, SLIT2, MMP1, DCHS1, STAT2, NPTX1, FBLN2, SVIL, FBLN5, ANXA11, CCBE1, FBN2, MFAP4, GALNT14

23

12.43

2.06E-02

EGF-like, type3

F10, LDLR, EGFL6, SCUBE2, FBLN2, FBLN5, CCBE1, ADAM33, FBN2, SLIT2

10

5.41

1.44E-02

system development

INHBA, RBP4, CTGF, DLX5, CHST11, FHL2, SORT1, MGP, FOXC1, NPR3, COL5A2, ANKH

12

6.32

5.08E-01

Z disc

SORBS2, PDLIM5, DMD, FHL2, HOMER1

5

2.63

2.77E-01

myofibril

SORBS2, PDLIM5, DMD, FHL2, HOMER1, TPM1

6

3.16

2.24E-01