Fig. 4
From: Precise mapping of the transcription start sites of human microRNAs using DROSHA knockout cells
Analysis of the host genes of intronic miRNAs. a Analysis of the sequencing graph encompassing EGFL7 gene, as an example. A part of the EGFL7 gene encompassing pre-miR-126, is shown. In the sequencing graph, exonic and intronic reads are depicted by black and gray colors, respectively. Note that only the RNA signals at the intron containing the pre-miR-126 are enriched in the DROSHA knockout cells. b Analysis of the host genes of intronic miRNAs. Among the authentic miRNAs [20], intronic miRNAs were selected for analysis (Additional file 4). Fold change of the read numbers corresponding to each genomic region was calculated (DROSHA knockout / wild-type cells). P value was calculated using two-sided paired t-test (* < 0.05)