Table 2 NCBI GEO datasets validation summary
From: DeSigN: connecting gene expression with therapeutics for drug repurposing and development
GEO reference | Reported drug | Expected drug sensitivity | DeSigN rank | DeSigN drug | Target | Connectivity Score | p-value |
|---|---|---|---|---|---|---|---|
GSE4342 | Gefitinib | Sensitive | 1 | Gefitinib | EGFR | 1.00 | 0.000 |
GSE16179 | Lapatinib | Sensitive | 6 | Lapatinib | EGFR, ERBB2 | 0.87 | 0.015 |
GSE9633 | Dasatinib | Sensitive | 6 | Dasatinib | ABL, SRC, KIT, PDGFR | 0.83 | 0.025 |
GSE35141 | Gemcitabine | Resistant | 129 | Gemcitabine | DNA replication | −0.83 | 0.025 |