Fig. 2

Repeat regions of herpesvirus genomes are enriched for PQS. a Enrichment of PQS in the repeat regions as compared to the rest of the genome: Average PQS densities in the repeat regions and in the rest of the genome of all full-length sequences available for each virus. The number of full-length sequences studied for each virus is shown in parentheses. Please see Additional file 1 for accession numbers. b The GC content in the repeat regions of human herpesviruses are higher than that in the rest of the genome. c PQS are enriched in native repeat regions within herpesvirus genomes compared to randomized repeat regions. Each repeat region in a herpesvirus genome was randomized 5 times. The fold change between average PQS density of native repeat regions and average PQS density of randomized repeat regions is plotted. HHV-3 was an exception with higher PQS densities in the randomized repeat regions. * denotes P < 0.01