Fig. 5

SnoRNA28 target conservation. Conservation of the interaction between the region upstream of D-box of snoRNA family snoR28 (right side) and the region around the 2’-O-methylated cytosine in 18S rRNA (left side). Target RNA segment and ASE are separated by &. The methylated residue is marked with M. The position of the predicted modification in the 18S rRNA sequence within each species is given at the end of each row. Red and green columns highlight conservation of the RNA-RNA interaction. Completely conserved base pairs are shown in red. Green columns mark base pairs with compensatory mutations. Lighter colors indicate loss of base pairs in individual species. The gray bars at the bottom correspond to the degree of sequence conservation. The last three snoR28 paralogs are more divergent and presumably address different targets