Fig. 1
From: The Drosophila transcriptional network is structured by microbiota
The microbiota changes transcriptional network structure in specific modules. a The heatmap shows the structure of pairwise gene-gene correlations amongst the Drosophila lines. Gene-gene coexpression is significantly greater in gnotobiotic flies than in axenic flies (Wilcoxon rank-sum, p < 0.00001). The largest changes in transcript-transcript correlations between axenic (top-right) and gnotobiotic (bottom-left) conditions are confined to specific transcriptional modules. Genes are organized by assignments to modules, represented by the colored side-bars. b Description of each module (Additional file 5: Table S3 for details). Significantly differential coexpression was determined by permutation testing (Additional file 6: Table S4). "Y" indicates differential coexpression within a module. c Network diagrams of differentially expressed transcriptional modules. Nodes represent genes, numbered by module assignment. Edges represent correlations between nodes above/below a threshold of Spearman's rho 0.75 or −0.75