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Table 3 Loss of coordinated COP9 gene expression in HNSCC

From: Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components

Normal vs. Tumor (paired 42)

Normal

GPS1

COPS2

COPS3

COPS4

COPS5

COPS6

COPS7A

COPS8

 GPS1

1

−0.059

0.303

0.369

0.385

0.75

0.522

0.519

 COPS2

−0.059

1

0.783

0.676

0.683

0.072

0.587

0.415

 COPS3

0.303

0.783

1

0.775

0.841

0.536

0.777

0.465

 COPS4

0.369

0.676

0.775

1

0.786

0.369

0.797

0.835

 COPS5

0.385

0.683

0.841

0.786

1

0.521

0.843

0.618

 p

0.012

6.25E-07

3.30E-12

6.90E-10

-

4.09E-04

2.37E-12

1.32E-05

 COPS6

0.75

0.072

0.536

0.369

0.521

1

0.479

0.296

 COPS7A

0.522

0.587

0.777

0.797

0.843

0.479

1

0.675

 COPS8

0.519

0.415

0.465

0.835

0.618

0.296

0.675

1

Tumor

GPS1

COPS2

COPS3

COPS4

COPS5

COPS6

COPS7A

COPS8

 GPS1

1.000

−0.091

0.055

0.012

0.212

0.360

−0.195

0.218

 COPS2

−0.091

1.000

0.126

−0.073

0.218

−0.271

−0.029

−0.066

 COPS3

0.055

0.126

1.000

0.043

0.033

0.342

−0.213

0.258

 COPS4

0.012

−0.073

0.043

1.000

0.024

−0.023

0.300

0.066

 COPS5

0.212

0.218

0.033

0.024

1.000

−0.053

−0.196

0.244

 p

0.177

0.165

0.836

0.88

-

0.741

0.213

0.12

 COPS6

0.360

−0.271

0.342

−0.023

−0.053

1.000

−0.041

0.205

 COPS7A

−0.195

−0.029

−0.213

0.300

−0.196

−0.041

1.000

−0.197

 COPS8

0.218

−0.066

0.258

0.066

0.244

0.205

−0.197

1.000

  1. Normal and matched HNSCC tissues (sample number = 42) were compared for their correlation coefficient values among the COP9 genes
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BMC Genomics

ISSN: 1471-2164

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