Skip to main content

Table 6 Enrichment scores for the COPS5 gene on KEGG pathways

From: Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components

  KEGG pathways ES Min Nh p
1 hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 0.919 −0.004 6 0.001
2 hsa00400 Phenylalanine 0.811 −0.028 3 0.038
3 hsa00190 Oxidative phosphorylation 0.797 0.000 106 0.000
4 hsa00630 Glyoxylate and dicarboxylate metabolism 0.752 −0.014 13 0.001
5 hsa00053 Ascorbate and aldarate metabolism 0.750 −0.083 6 0.001
6 hsa00062 Fatty acid elongation in mitochondria 0.745 −0.027 8 0.004
7 hsa03050 Proteasome 0.734 −0.004 41 0.000
8 hsa00640 Propanoate metabolism 0.698 −0.003 29 0.000
9 hsa00620 Pyruvate metabolism 0.691 −0.006 34 0.000
10 hsa04260 Cardiac muscle contraction 0.676 −0.001 56 0.000
  1. All KEGG pathways found in the entire gene list of the TCGA RNA expression database (199) were individually scanned through the r COPS5 alignment, and the maximum (ES) as well as minimum (Phit - Pmiss) were calculated as previously described [1]. The KEGG pathways that generated the 10 highest ES values are shown. Nh: number of genes belonging to a KEGG pathway in the entire list. A p value for a particular KEGG pathway with an Nh (= Nk) was determined using mean and standard deviation obtained by the following method. Nk genes were randomly selected from the r COPS5 list and calculated an ES value, which was reiterated for 1000 times to generate the mean and standard deviation of ES