Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components

Table 6 Enrichment scores for the COPS5 gene on KEGG pathways

	KEGG pathways		ES	Min	Nh	p
1	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	0.919	−0.004	6	0.001
2	hsa00400	Phenylalanine	0.811	−0.028	3	0.038
3	hsa00190	Oxidative phosphorylation	0.797	0.000	106	0.000
4	hsa00630	Glyoxylate and dicarboxylate metabolism	0.752	−0.014	13	0.001
5	hsa00053	Ascorbate and aldarate metabolism	0.750	−0.083	6	0.001
6	hsa00062	Fatty acid elongation in mitochondria	0.745	−0.027	8	0.004
7	hsa03050	Proteasome	0.734	−0.004	41	0.000
8	hsa00640	Propanoate metabolism	0.698	−0.003	29	0.000
9	hsa00620	Pyruvate metabolism	0.691	−0.006	34	0.000
10	hsa04260	Cardiac muscle contraction	0.676	−0.001	56	0.000

All KEGG pathways found in the entire gene list of the TCGA RNA expression database (199) were individually scanned through the r _COPS5 alignment, and the maximum (ES) as well as minimum (P_hit - P_miss) were calculated as previously described [1]. The KEGG pathways that generated the 10 highest ES values are shown. N_h: number of genes belonging to a KEGG pathway in the entire list. A p value for a particular KEGG pathway with an N_h (= N_k) was determined using mean and standard deviation obtained by the following method. N_k genes were randomly selected from the r _COPS5 list and calculated an ES value, which was reiterated for 1000 times to generate the mean and standard deviation of ES

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