Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components

Table 7 Synchronized expression of the COP9 genes in the matched tissues of normal and lung squamous cell carcinoma

Correlation Coefficient among COP9 genes, Lung Squamous Cell Carcinoma (n = 50)
Normal	GPS1	COPS2	COPS3	COPS4	COPS5	COPS6	COPS7A	COPS7B	COPS8
GPS1	1.000	−0.092	0.268	0.269	0.278	0.717	0.781	0.194	0.244
COPS2	−0.092	1.000	0.792	0.844	0.742	0.300	0.193	−0.432	0.725
COPS3	0.268	0.792	1.000	0.910	0.859	0.557	0.455	−0.373	0.837
COPS4	0.269	0.844	0.910	1.000	0.909	0.603	0.524	−0.279	0.910
COPS5	0.278	0.742	0.859	0.909	1.000	0.550	0.497	−0.141	0.859
p	0.051	6.85E-10	1.33E-15	0.00E + 00	-	3.49E-05	2.40E-04	0.329	1.55E-15
COPS6	0.717	0.300	0.557	0.603	0.550	1.000	0.716	−0.009	0.602
COPS7A	0.781	0.193	0.455	0.524	0.497	0.716	1.000	0.197	0.461
COPS7B	0.194	−0.432	−0.373	−0.279	−0.141	−0.009	0.197	1.000	−0.257
COPS8	0.244	0.725	0.837	0.910	0.859	0.602	0.461	−0.257	1.000
Tumor	GPS1	COPS2	COPS3	COPS4	COPS5	COPS6	COPS7A	COPS7B	COPS8
GPS1	1.000	0.059	0.261	0.228	0.109	0.529	0.307	0.304	0.193
COPS2	0.059	1.000	0.413	0.488	0.142	0.105	0.143	−0.180	0.207
COPS3	0.261	0.413	1.000	0.240	0.267	0.466	0.320	−0.075	0.137
COPS4	0.228	0.488	0.240	1.000	0.235	0.082	0.023	0.076	0.177
COPS5	0.109	0.142	0.267	0.235	1.000	0.233	0.103	0.212	0.170
p	0.452	0.326	0.061	0.101	-	0.103	0.477	0.139	0.239
COPS6	0.529	0.105	0.466	0.082	0.233	1.000	0.640	0.120	0.180
COPS7A	0.307	0.143	0.320	0.023	0.103	0.640	1.000	−0.094	0.008
COPS7B	0.304	−0.180	−0.075	0.076	0.212	0.120	−0.094	1.000	0.613
COPS8	0.193	0.207	0.137	0.177	0.170	0.180	0.008	0.613	1.000

The analysis was carried out in the same way as for Table 3. Values in bold letters indicate significantly high COSP5 correlation with other COP9 components

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