Table 4 The 10 top-ranked miRNAs and their target gene involvement in the KEGG pathway

Hippo signaling pathway

33

3

Fatty acid elongation

3

2

Proteoglycans in cancer

60

5

Fatty acid metabolism

2

2

Transcriptional misregulation in cancer

55

2

ECM-receptor interaction

16

2

Fatty acid degradation

1

1

Chronic myeloid leukemia

33

2

Glioma

25

3

TGF-beta signaling pathway

29

2

Adherens junction

27

2

Biosynthesis of unsaturated fatty acids

2

2

Viral carcinogenesis

50

3

Pathways in cancer

59

1

Pancreatic cancer

26

2

Metabolism of xenobiotics by cytochrome P450

2

1

Signaling pathways regulating pluripotency of stem cells

43

2

Central carbon metabolism in cancer

24

2

Non-small cell lung cancer

15

1

Colorectal cancer

23

2

Thyroid hormone signaling pathway

42

2

Other types of O-glycan biosynthesis

8

1

Lysine degradation

4

1

Spliceosome

24

2

Small cell lung cancer

23

1

Prostate cancer

26

2

Melanoma

22

2

Insulin signaling pathway

31

1

Antigen processing and presentation

5

1

Shigellosis

6

1

Cell cycle

22

1

Steroid biosynthesis

1

1

FoxO signaling pathway

25

1

Sulfur relay system

2

2

Estrogen signaling pathway

19

1

Long-term depression

10

1

Base excision repair

2

1

Protein processing in endoplasmic reticulum

10

1

mRNA surveillance pathway

7

1

RNA transport

29

1

AMPK signaling pathway

23

1

Huntington’s disease

2

1

Adipocytokine signaling pathway

13

1

Allograft rejection

3

1

Cocaine addiction

8

1

Purine metabolism

5

1

Renin-angiotensin system

1

1

Valine, leucine and isoleucine degradation

1

1

Valine, leucine and isoleucine biosynthesis

1

1