Skip to main content

Table 1 POLA2 and its interactants based on published experimental evidence

From: Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells

Gene of interest
 POLA2 Polymerase (DNA) alpha 2, accessory subunit 11q13.1 21 GO:0003887 GO:0006260   -
 AKTIP AKT interacting protein 16q12.2 11 GO:0001934 GO:0005515   Two-hybrid
 APP Amyloid beta precursor protein 21q21.3 20 GO:0045931 GO:0051425   Reconstituted Complex
 ASCC2 Activating signal cointegrator 1 complex subunit 2 22q12.1 23 GO:0006355    Two-hybrid
 ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 10p15.1 10 GO:0006754 GO:0016887   Two-hybrid
 CAPN1 Calpain 1 11q13 24 GO:0005515 GO:0008284   Affinity Capture-MS
 CIAO1 Cytosolic iron-sulfur assembly component 1 2q11.2 7 GO:0005515 GO:0008284   Affinity Capture-MS
 CPE Carboxypeptidase E 4q32.3 9 GO:0050839 GO:0072657   Two-hybrid
 CRELD1 Cysteine rich with EGF like domains 1 3p25.3 12 GO:0005509    Two-hybrid
 DCP2 Decapping mRNA 2 5q22.2 11 GO:0005515 GO:0006402   Two-hybrid
 DDX24 DEAD-box helicase 24 14q32 9 GO:0044822    Two-hybrid
 DHX34 DEAH-box helicase 34 19q13.3 21 GO:0044822    Two-hybrid
 EIF6 Eukaryotic translation initiation factor 6 20q12 8 GO:0005515    Two-hybrid
 EPB41L1 Erythrocyte membrane protein band 4.1 like 1 20q11.2-q12 37 GO:0005515    Co-fractionation
 EZH2 Enhancer of zeste 2 polycomb repressive complex 2 subunit 7q35-q36 25 GO:0005515 GO:0031490 GO:0042127 Two-hybrid
 FGFR3 Fibroblast growth factor receptor 3 4p16.3 19 GO:0005515 GO:0008543 GO:0042127 Two-hybrid
 FRZB Frizzled-related protein 2q32.1 6 GO:0017147 GO:0043065   Two-hybrid
 HDAC6 Histone deacetylase 6 Xp11.23 32 GO:0005515 GO:0016575 GO:0045892 Two-hybrid
 HELB Helicase (DNA) B 12q14.3; 12q 14 GO:0006260 GO:0044822   Reconstituted Complex
 HEXIM1 Hexamethylene bis-acetamide inducible 1 17q21.31 1 GO:0005515 GO:0045892   Co-fractionation
 IGFBP3 Insulin like growth factor binding protein 3 7p12.3 5 GO:0005515 GO:0043065   Two-hybrid
 KCNE3 Potassium voltage-gated channel subfamily E regulatory subunit 3 11q13.4 3 GO:0005515 GO:0015459   Two-hybrid
 KLF6 Kruppel-like factor 6 10p15 4 GO:0005515 GO:0045893   Two-hybrid
 LRPAP1 LDL receptor related protein associated protein 1 4p16.3 9 GO:0070326    Two-hybrid
 MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 4q27 5 GO:0005515 GO:0007093   Affinity Capture-MS
 MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component 10q24-q25 32 GO:0005515 GO:0045893   Affinity Capture-MS
 NR4A1 Nuclear receptor subfamily 4 group A member 1 12q13 13 GO:0003677 GO:0005515 GO:0045786 Two-hybrid
 PARP1 Poly(ADP-ribose) polymerase 1 1q41-q42 23 GO:0003677 GO:0005515 GO:0006281 Affinity Capture-Western; Far Western
 POLA1 Polymerase (DNA) alpha 1, catalytic subunit Xp22.1-p21.3 38 GO:0003887 GO:0006260   Co-fractionation; Reconstituted Complex
 POLD2 Polymerase (DNA) delta 2, accessory subunit 7p13 13 GO:0003887 GO:0006260   Co-fractionation
 POP7 POP7 homolog, ribonuclease P/MRP subunit 7q22 2 GO:0005515 GO:0044822   Co-fractionation
 PRIM1 Primase (DNA) subunit 1 12q13 13 GO:0006270    Co-fractionation
 PRIM2 Primase (DNA) subunit 2 6p12-p11.1 19 GO:0006270    Co-fractionation
 PRPF38A Pre-mRNA processing factor 38A 1p32.3 10 GO:0005515 GO:0044822   Two-hybrid
 RAE1 Ribonucleic acid export 1 20q13.31 15 GO:0003723    Affinity Capture-MS
 RBM23 RNA binding motif protein 23 14q11.2 19 GO:0003723 GO:0005515   Two-hybrid
 REPIN1 Replication initiator 1 7q36.1 6 GO:0003677 GO:0006260 GO:0044822 Co-fractionation
 SCYL1 SCY1 like pseudokinase 1 11q13 18 GO:0006355 GO:0006890   Co-fractionation
 SETDB1 SET domain bifurcated 1 1q21 22 GO:0005515 GO:1990841   Two-hybrid
 SNU13 SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) 22q13 5 GO:0005515 GO:0044822 GO:0051117 Two-hybrid
 STK40 Serine/threonine kinase 40 1p34.3 12 GO:0010468 GO:0043066 GO:0043408 Two-hybrid
 UBE2O Ubiquitin conjugating enzyme E2 O 17q25.1 19 GO:0005515 GO:0006513 GO:0044822 Co-fractionation
 ULK2 Unc-51 like autophagy activating kinase 2 17p11.2 29 GO:0005515 GO:0010506   Two-hybrid
 XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 10q25.3 23 GO:0042803    Two-hybrid
 XPO1 Exportin 1 2p15 29 GO:0003723 GO:0005515 GO:0006611 Affinity Capture-MS
  1. Gene symbol, gene name, chromosomal location, number of exons and Gene Ontology accession numbers of each gene are shown. A total of 44 interactants were found for POLA2, as inferred from physical interactions, sequence or structural similarities as well as direct experimental assays. Brief description of the experimental source is given. Data were compiled from the National Center for Biotechnology Information (NCBI) and Gene Ontology (GO) framework databases