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Table 1 POLA2 and its interactants based on published experimental evidence

From: Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells

GENE SYMBOL

GENE NAME

CHROMOSOMAL LOCATION

EXON COUNT

GENE ONTOLOGY (ACCESSION)

EXPERIMENTAL SOURCE

Gene of interest

 POLA2

Polymerase (DNA) alpha 2, accessory subunit

11q13.1

21

GO:0003887

GO:0006260

 

-

Interactants

 AKTIP

AKT interacting protein

16q12.2

11

GO:0001934

GO:0005515

 

Two-hybrid

 APP

Amyloid beta precursor protein

21q21.3

20

GO:0045931

GO:0051425

 

Reconstituted Complex

 ASCC2

Activating signal cointegrator 1 complex subunit 2

22q12.1

23

GO:0006355

  

Two-hybrid

 ATP5C1

ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1

10p15.1

10

GO:0006754

GO:0016887

 

Two-hybrid

 CAPN1

Calpain 1

11q13

24

GO:0005515

GO:0008284

 

Affinity Capture-MS

 CIAO1

Cytosolic iron-sulfur assembly component 1

2q11.2

7

GO:0005515

GO:0008284

 

Affinity Capture-MS

 CPE

Carboxypeptidase E

4q32.3

9

GO:0050839

GO:0072657

 

Two-hybrid

 CRELD1

Cysteine rich with EGF like domains 1

3p25.3

12

GO:0005509

  

Two-hybrid

 DCP2

Decapping mRNA 2

5q22.2

11

GO:0005515

GO:0006402

 

Two-hybrid

 DDX24

DEAD-box helicase 24

14q32

9

GO:0044822

  

Two-hybrid

 DHX34

DEAH-box helicase 34

19q13.3

21

GO:0044822

  

Two-hybrid

 EIF6

Eukaryotic translation initiation factor 6

20q12

8

GO:0005515

  

Two-hybrid

 EPB41L1

Erythrocyte membrane protein band 4.1 like 1

20q11.2-q12

37

GO:0005515

  

Co-fractionation

 EZH2

Enhancer of zeste 2 polycomb repressive complex 2 subunit

7q35-q36

25

GO:0005515

GO:0031490

GO:0042127

Two-hybrid

 FGFR3

Fibroblast growth factor receptor 3

4p16.3

19

GO:0005515

GO:0008543

GO:0042127

Two-hybrid

 FRZB

Frizzled-related protein

2q32.1

6

GO:0017147

GO:0043065

 

Two-hybrid

 HDAC6

Histone deacetylase 6

Xp11.23

32

GO:0005515

GO:0016575

GO:0045892

Two-hybrid

 HELB

Helicase (DNA) B

12q14.3; 12q

14

GO:0006260

GO:0044822

 

Reconstituted Complex

 HEXIM1

Hexamethylene bis-acetamide inducible 1

17q21.31

1

GO:0005515

GO:0045892

 

Co-fractionation

 IGFBP3

Insulin like growth factor binding protein 3

7p12.3

5

GO:0005515

GO:0043065

 

Two-hybrid

 KCNE3

Potassium voltage-gated channel subfamily E regulatory subunit 3

11q13.4

3

GO:0005515

GO:0015459

 

Two-hybrid

 KLF6

Kruppel-like factor 6

10p15

4

GO:0005515

GO:0045893

 

Two-hybrid

 LRPAP1

LDL receptor related protein associated protein 1

4p16.3

9

GO:0070326

  

Two-hybrid

 MAD2L1

MAD2 mitotic arrest deficient-like 1 (yeast)

4q27

5

GO:0005515

GO:0007093

 

Affinity Capture-MS

 MMS19

MMS19 homolog, cytosolic iron-sulfur assembly component

10q24-q25

32

GO:0005515

GO:0045893

 

Affinity Capture-MS

 NR4A1

Nuclear receptor subfamily 4 group A member 1

12q13

13

GO:0003677

GO:0005515

GO:0045786

Two-hybrid

 PARP1

Poly(ADP-ribose) polymerase 1

1q41-q42

23

GO:0003677

GO:0005515

GO:0006281

Affinity Capture-Western; Far Western

 POLA1

Polymerase (DNA) alpha 1, catalytic subunit

Xp22.1-p21.3

38

GO:0003887

GO:0006260

 

Co-fractionation; Reconstituted Complex

 POLD2

Polymerase (DNA) delta 2, accessory subunit

7p13

13

GO:0003887

GO:0006260

 

Co-fractionation

 POP7

POP7 homolog, ribonuclease P/MRP subunit

7q22

2

GO:0005515

GO:0044822

 

Co-fractionation

 PRIM1

Primase (DNA) subunit 1

12q13

13

GO:0006270

  

Co-fractionation

 PRIM2

Primase (DNA) subunit 2

6p12-p11.1

19

GO:0006270

  

Co-fractionation

 PRPF38A

Pre-mRNA processing factor 38A

1p32.3

10

GO:0005515

GO:0044822

 

Two-hybrid

 RAE1

Ribonucleic acid export 1

20q13.31

15

GO:0003723

  

Affinity Capture-MS

 RBM23

RNA binding motif protein 23

14q11.2

19

GO:0003723

GO:0005515

 

Two-hybrid

 REPIN1

Replication initiator 1

7q36.1

6

GO:0003677

GO:0006260

GO:0044822

Co-fractionation

 SCYL1

SCY1 like pseudokinase 1

11q13

18

GO:0006355

GO:0006890

 

Co-fractionation

 SETDB1

SET domain bifurcated 1

1q21

22

GO:0005515

GO:1990841

 

Two-hybrid

 SNU13

SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)

22q13

5

GO:0005515

GO:0044822

GO:0051117

Two-hybrid

 STK40

Serine/threonine kinase 40

1p34.3

12

GO:0010468

GO:0043066

GO:0043408

Two-hybrid

 UBE2O

Ubiquitin conjugating enzyme E2 O

17q25.1

19

GO:0005515

GO:0006513

GO:0044822

Co-fractionation

 ULK2

Unc-51 like autophagy activating kinase 2

17p11.2

29

GO:0005515

GO:0010506

 

Two-hybrid

 XPNPEP1

X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

10q25.3

23

GO:0042803

  

Two-hybrid

 XPO1

Exportin 1

2p15

29

GO:0003723

GO:0005515

GO:0006611

Affinity Capture-MS

  1. Gene symbol, gene name, chromosomal location, number of exons and Gene Ontology accession numbers of each gene are shown. A total of 44 interactants were found for POLA2, as inferred from physical interactions, sequence or structural similarities as well as direct experimental assays. Brief description of the experimental source is given. Data were compiled from the National Center for Biotechnology Information (NCBI) and Gene Ontology (GO) framework databases