Table 1 A matrix to understand the three approaches in terms of the mode of binding used and the pool of amino acids for introducing mutations in the zinc finger template
Mode of Binding | Amino acid mutation | |
|---|---|---|
Consensus pool of amino acids for introducing mutations in the ZFP | All amino acid possibilities for introducing mutations in the ZFP | |
Modular | Approach 1 | Approach 3 |
Synergistic | Approach 2 | N.Da |