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Table 1 A matrix to understand the three approaches in terms of the mode of binding used and the pool of amino acids for introducing mutations in the zinc finger template

From: Exploiting the recognition code for elucidating the mechanism of zinc finger protein-DNA interactions

Mode of Binding Amino acid mutation
Consensus pool of amino acids for introducing mutations in the ZFP All amino acid possibilities for introducing mutations in the ZFP
Modular Approach 1 Approach 3
Synergistic Approach 2 N.Da
  1. aND: not determined due to enormity of the computational complexity