Fig. 2
Global map of RNA degradation kinetics. a Genes are classified as “not expressed” or “expressed” categories according to expression level. The expressed genes are further categorized according to mean degradation rates, quick, slow, stable, or low reliability, in which calculation of degradation rates of genes were failed at 4 or more time points. Numbers represent number of genes in the category. b Genes in quick, slow or stable categories are ordered by mean degradation rates and heat map image of the mean degradation rates is shown. c Histogram of mean degradation rates of genes in unstable (quick or slow) category. Genes below or above the green line (degradation rate of 0.325 h−1) are categorized as “slow” or “quick”, respectively. d Heat map image of mean expression levels of genes are shown in the same order as shown in (b). e Box plot of mean expression levels for each category. One-sided Mann-Whitney test was performed with Bonferroni correction; *p < 1 × 10−5. f Bar plot of fractions of up-regulated (red), down-regulated (blue), or neither (grey) genes in each category of degradation. The numbers shown in boxes represent fractions (%), and absolute number of genes in parenthesis. Fisher exact test was performed to compare the numbers of up-regulated genes in two sets with Bonferroni correction; *p < 0.05. g Box plot of length of 3′ UTRs of the genes in each category. One-sided Mann-Whitney test was performed with Bonferroni correction; *p < 1 × 10−3