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Table 3 Putative transporters in Cryptosporidium spp. and other common apicomplexan parasitesa

From: Evolution of mitosome metabolism and invasion-related proteins in Cryptosporidium

Substrates Cellular location Cpar Chom Cubi Cand Pfal Tgon
Hexose   2 2 2 2 2 5
Triose phosphate Plasma/Apicoplast membrane 8 5 8 8 4 4
Amino acids Plasma membrane 10 10 10 12 1 6
Nucleobase/nucleoside Plasma membrane 1 1 1 1 4 4
Nucleotide-sugar Plasma membrane 3 3 3 2 1 4
Folate/pterine Plasma membrane 1 1 1 1 2 7
Formate/nitrite   0 0 0 0 1 3
GABA (aminobutanoate) Plasma/Mitochondrial membrane 0 0 0 0 2 5
Acetyl-CoA   1 0 1 1 1 1
Chloride   0 0 0 0 0 2
Inorganic phosphate   0 0 0 0 1 1
Sulfate   1 1 1 1 1 4
Sodium/potassium/calcium   2 2 2 3 0 9
Zinc   2 2 2 2 2 4
Copper   1 1 1 1 2 3
Choline Plasma membrane 0 0 0 0 1 2
Cadmium/zinc/cobalt (efflux) Plasma membrane 1 1 1 1 1 1
Glycerol/water Plasma membrane 0 0 0 0 2 2
ABC transporterb Plasma membrane 21 18 21 21 16 24
Mitochondrial carrierb Mitochondrial membrane 9 7 6 13 14 21
  1. aThe detection of these transporter proteins was based on the Pfam search results
  2. bABC transporters and mitochondrial carriers have a broad range of substrates
  3. Cpar Cryptosporidium parvum, Chom C. hominis, Cubi C. ubiquitum, Cand C. andersoni, Pfal Plasmodium falciparum Pfal, Tgon Toxoplasma gondii