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Table 3 Putative transporters in Cryptosporidium spp. and other common apicomplexan parasitesa

From: Evolution of mitosome metabolism and invasion-related proteins in Cryptosporidium

Substrates

Cellular location

Cpar

Chom

Cubi

Cand

Pfal

Tgon

Hexose

 

2

2

2

2

2

5

Triose phosphate

Plasma/Apicoplast membrane

8

5

8

8

4

4

Amino acids

Plasma membrane

10

10

10

12

1

6

Nucleobase/nucleoside

Plasma membrane

1

1

1

1

4

4

Nucleotide-sugar

Plasma membrane

3

3

3

2

1

4

Folate/pterine

Plasma membrane

1

1

1

1

2

7

Formate/nitrite

 

0

0

0

0

1

3

GABA (aminobutanoate)

Plasma/Mitochondrial membrane

0

0

0

0

2

5

Acetyl-CoA

 

1

0

1

1

1

1

Chloride

 

0

0

0

0

0

2

Inorganic phosphate

 

0

0

0

0

1

1

Sulfate

 

1

1

1

1

1

4

Sodium/potassium/calcium

 

2

2

2

3

0

9

Zinc

 

2

2

2

2

2

4

Copper

 

1

1

1

1

2

3

Choline

Plasma membrane

0

0

0

0

1

2

Cadmium/zinc/cobalt (efflux)

Plasma membrane

1

1

1

1

1

1

Glycerol/water

Plasma membrane

0

0

0

0

2

2

ABC transporterb

Plasma membrane

21

18

21

21

16

24

Mitochondrial carrierb

Mitochondrial membrane

9

7

6

13

14

21

  1. aThe detection of these transporter proteins was based on the Pfam search results
  2. bABC transporters and mitochondrial carriers have a broad range of substrates
  3. Cpar Cryptosporidium parvum, Chom C. hominis, Cubi C. ubiquitum, Cand C. andersoni, Pfal Plasmodium falciparum Pfal, Tgon Toxoplasma gondii