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Table 2 Genes differentially expressed in ISIAH and WAG adrenal glands and referred to in Rat Genome Database as associated with metabolic diseases

From: Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats

Gene symbol

Gene_ID

log2

(fold_change) ISIAH/WAG

Gene definition

Abca1 a b d e

313210

1.12

ATP-binding cassette, subfamily A (ABC1), member 1

Abcg2

312382

1.09

ATP-binding cassette, subfamily G (WHITE), member 2

Acacb a

116719

0.98

acetyl-CoA carboxylase beta

Acad9

294973

0.63

acyl-CoA dehydrogenase family, member 9

Acadsb

25618

−0.71

acyl-CoA dehydrogenase, short/branched chain

Acot2

192272

−0.55

acyl-CoA thioesterase 2)

Acp5

25732

−1.54

acid phosphatase 5, tartrate resistant

Ada c

24165

0.75

adenosine deaminase

Adipoq a d

246253

1.10

adiponectin, C1Q and collagen domain containing

Adrb3 a

25645

2.44

adrenergic, beta-3-, receptor

Adssl1

684425

0.91

adenylosuccinate synthase like 1

Agt a

24179

2.28

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Ahsg a d

25373

detected only in ISIAH rats

alpha-2-HS-glycoprotein

Aif1

29427

0.95

allograft inflammatory factor 1

Ak1

24183

−0.72

adenylate kinase 1

Alas1

65155

0.75

aminolevulinate, delta-, synthase 1

Alpl a b d

25586

−1.32

alkaline phosphatase, liver/bone/kidney

Anxa5

25673

−0.97

annexin A5

Aox1

54349

1.74

aldehyde oxidase 1

Apoc1 d

25292

−0.90

apolipoprotein C-I

Aqp1

25240

−0.49

aquaporin 1

Arsb

25227

−0.49

arylsulfatase B

Aspa

79251

1.01

aspartoacylase

Atp1a2 a

24212

1.26

ATPase, Na+/K+ transporting, alpha 2 polypeptide

Bche a d

65036

1.32

butyrylcholinesterase

C1qa

298566

0.77

complement component 1, q subcomponent, A chain

C3 a

24232

2.06

complement component 3

Cartpt

29131

−3.09

CART prepropeptide

Casq1

686019

−1.87

calsequestrin 1 (fast-twitch, skeletal muscle)

Casq2

29209

2.32

calsequestrin 2 (cardiac muscle)

Ccl11 c

29397

1.41

chemokine (C-C motif) ligand 11

Cd36 a

29184

1.04

CD36 molecule (thrombospondin receptor)

Cfb

294257

0.65

complement factor B

Cfh

155012

0.76

complement factor H

Chek2 a

114212

−0.92

checkpoint kinase 2

Cidec

500292

1.65

cell death-inducing DFFA-like effector c

Col1a1

29393

0.80

collagen, type I, alpha 1

Cpox

304024

0.50

coproporphyrinogen oxidase

Crp a d

25419

detected only in ISIAH rats

C-reactive protein, pentraxin-related

Cx3cr1

171056

0.75

chemokine (C-X3-C motif) receptor 1

Cxcl10

245920

−1.90

chemokine (C-X-C motif) ligand 10

Cxcl12

24772

0.91

chemokine (C-X-C motif) ligand 12

Cyba a

79129

0.68

cytochrome b-245, alpha polypeptide

Cyp2e1

25086

1.91

cytochrome P450, family 2, subfamily e, polypeptide 1

Dab2

79128

0.79

disabled homolog 2 (Drosophila)

Dcaf12l1

313296

−1.59

DDB1 and CUL4 associated factor 12-like 1

Dcn

29139

0.54

decorin

Dgat1 a d

84497

0.63

diacylglycerol O-acyltransferase 1

Dusp1 c

114856

−0.94

dual specificity phosphatase 1

Ednrb

50672

0.82

endothelin receptor type B

Ehhadh

171142

2.01

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

Entpd5

314312

−1.00

ectonucleoside triphosphate diphosphohydrolase 5

Ephx2 a b d e

65030

4.37

epoxide hydrolase 2, cytoplasmic

Ercc4

304719

−1.12

excision repair cross-complementing rodent repair deficiency, complementation group 4

F13a1

60327

1.00

coagulation factor XIII, A1 polypeptide

Fabp4 a

79451

1.61

fatty acid binding protein 4, adipocyte

Fam111a

499322

3.85

family with sequence similarity 111, member A

Fam126a

499975

−0.72

family with sequence similarity 126, member A

Fas

246097

−0.80

Fas (TNF receptor superfamily, member 6)

Fbn1

83727

0.69

fibrillin 1

Fgb

24366

detected only in ISIAH rats

fibrinogen beta chain

Fgg

24367

1.47

fibrinogen gamma chain

Fmo3

84493

0.57

flavin containing monooxygenase 3

Fn1

25661

0.76

fibronectin 1

Foxo1 a

84482

−0.86

forkhead box O1

Fus

317385

0.65

fused in sarcoma

Gabbr1

81657

1.11

gamma-aminobutyric acid (GABA) B receptor 1

Galns

292073

0.81

galactosamine (N-acetyl)-6-sulfate sulfatase

Gas6

58935

0.50

growth arrest specific 6

Gatm

81660

−1.26

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

Gcgr

24953

1.02

glucagon receptor

Gfpt2

360518

1.51

glutamine-fructose-6-phosphate transaminase 2

Gk

79223

−0.63

glycerol kinase

Glrx

64045

0.66

glutaredoxin (thioltransferase)

Gria1

50592

−2.39

glutamate receptor, ionotropic, AMPA 1

Gstp1

24426

−0.53

glutathione S-transferase pi 1

Hap1

29430

−0.61

huntingtin-associated protein 1

Hdac4

363287

0.73

histone deacetylase 4

Hmgb1

25459

−0.84

high mobility group box 1

Hmgcr a b d

25675

0.63

3-hydroxy-3-methylglutaryl-CoA reductase

Hmox1 a

24451

−0.69

heme oxygenase (decycling) 1

Hp a b c d

24464

1.10

haptoglobin

Hsd11b2

25117

−1.47

hydroxysteroid 11-beta dehydrogenase 2

Hspa1a

24472

0.70

heat shock 70kD protein 1A

Hyal1

367166

0.49

hyaluronoglucosaminidase 1

Ifih1

499801

0.69

interferon induced with helicase C domain 1

Igf1

24482

−2.12

insulin-like growth factor 1

Il1r1

25663

0.86

interleukin 1 receptor, type I

Iscu

288740

−0.65

iron-sulfur cluster scaffold homolog (E, coli)

Isg15

298693

0.95

ISG15 ubiquitin-like modifier

Itga2

170921

−1.29

integrin, alpha 2

Itgav a c

296456

−0.58

integrin, alpha V

Jak2 c

24514

−0.63

Janus kinase 2

Jak3

25326

−0.57

Janus kinase 3

Jam3

315509

0.58

junctional adhesion molecule 3

Kcnma1

83731

0.77

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Lcat d

24530

0.97

lecithin cholesterol acyltransferase

Ldlr b d e

300438

0.93

low density lipoprotein receptor

LOC689064

689064

2.02

beta-globin

Loxl1

315714

0.50

lysyl oxidase-like 1

Lpl a d e

24539

0.52

lipoprotein lipase

Lrrk2

300160

1.12

leucine-rich repeat kinase 2

Lyz2

25211

0.80

lysozyme 2

Mgp

25333

0.48

matrix Gla protein

Mpo

303413

4.46

myeloperoxidase

Mpz

24564

1.69

myelin protein zero

Mt2A

689415

−1.05

metallothionein 2A

Myeov2

681389

−0.53

myeloma overexpressed 2

Myo5b

25132

−1.13

myosin Vb

Ndufaf2

361894

−0.85

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2

Nefh

24587

1.44

neurofilament, heavy polypeptide

Nefm

24588

−0.79

neurofilament, medium polypeptide

Nr1d1

252917

−0.57

nuclear receptor subfamily 1, group D, member 1

Nucb2

59295

−0.64

nucleobindin 2

Oxct1

690163

−0.86

3-oxoacid CoA transferase 1

P2ry2

29597

−1.31

purinergic receptor P2Y, G-protein coupled, 2

Pah

24616

−0.86

phenylalanine hydroxylase

Pck1 c

362282

3.83

phosphoenolpyruvate carboxykinase 1 (soluble)

Pfkfb1

24638

1.58

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Phgdh

58835

−1.93

phosphoglycerate dehydrogenase

Pik3r1 a

25513

0.50

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Pla2g7 a

301265

−0.97

phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

Plau d

25619

−0.78

plasminogen activator, urokinase

Plin1

25629

2.04

perilipin 1

Postn

361945

1.30

periostin, osteoblast specific factor

Ppard a

25682

0.56

peroxisome proliferator-activated receptor delta

Pparg a d

25664

1.01

peroxisome proliferator-activated receptor gamma

Ppt1

29411

0.48

palmitoyl-protein thioesterase 1

Prkcb a c

25023

0.90

protein kinase C, beta

Psmb9

24967

0.47

proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

Ptprn

116660

−0.75

protein tyrosine phosphatase, receptor type, N

Rbp4

25703

1.83

retinol binding protein 4, plasma

Retn a

246250

2.26

resistin

RGD1562200

363471

0.84

patatin-like phospholipase domain-containing protein 4-like

RT1-Ba c

309621

0.49

RT1 class II, locus Ba

RT1-Da

294269

0.80

RT1 class II, locus Da

RT1-Db1

294270

0.91

RT1 class II, locus Db1

S100b

25742

−1.72

S100 calcium binding protein B

Scd1

246074

2.16

stearoyl-Coenzyme A desaturase 1

Scn1b

29686

−0.56

sodium channel, voltage-gated, type I, beta

Serpina1 a

24648

0.77

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin, member 1

Serpine1 a

24617

−2.04

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Slc11a1

316519

0.69

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

Slc16a12

309525

0.91

solute carrier family 16, member 12 (monocarboxylic acid transporter 12)

Slc4a4

84484

0.96

solute carrier family 4, sodium bicarbonate cotransporter, member 4

Slc7a7

83509

−0.69

solute carrier family 7 (amino acid transporter light chain, y%2BL system), member 7

Slc8a1

29715

0.58

solute carrier family 8 (sodium/calcium exchanger), member 1

Slc9a3

24784

4.24

solute carrier family 9 (sodium/hydrogen exchanger), member 3

Sod2

24787

0.75

superoxide dismutase 2, mitochondrial

Sorbs1 a

686098

−0.85

sorbin and SH3 domain containing 1

Spg11

311372

−0.55

spastic paraplegia 11 (autosomal recessive)

Spp1

25353

−0.56

secreted phosphoprotein 1

Stat5b

25126

−0.50

signal transducer and activator of transcription 5B

Tap1

24811

0.84

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Thbs1

445442

0.64

thrombospondin 1

Tnc

116640

1.74

tenascin C

Trpc6

89823

0.85

transient receptor potential cation channel, subfamily C, member 6

Ttr

24856

3.93

transthyretin

Uchl5

360853

−0.57

ubiquitin carboxyl-terminal hydrolase L5

Ucp1 a

24860

detected only in ISIAH rats

uncoupling protein 1 (mitochondrial, proton carrier)

Unc13a

64829

−1.01

unc-13 homolog A (C, elegans)

Vcam1 a d

25361

0.78

vascular cell adhesion molecule 1

Vip

117064

−1.57

vasoactive intestinal peptide

Vldlr b d

25696

−0.61

very low density lipoprotein receptor

Wfs1

83725

1.77

Wolfram syndrome 1 homolog (human)

Xdh

497811

−0.88

xanthine dehydrogenase

  1. Genes associated with: a-insulin resistance; b - hypercholesterolemia; c - hyperglycemia; d -hyperlipidemia; e - hyperlipoproteinemias; ISIAH and WAG – rat strains used in the study