The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions

Moskalev, Alexey; Shaposhnikov, Mikhail; Proshkina, Ekaterina; Belyi, Alexey; Fedintsev, Alexander; Zhikrivetskaya, Svetlana; Guvatova, Zulfiya; Sadritdinova, Asiya; Snezhkina, Anastasia; Krasnov, George; Kudryavtseva, Anna

doi:10.1186/s12864-016-3356-0

Table 2 The effect of age on survival of Drosophila after exposure to stresses

From: The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions

Stress and genotype of flies	Age (days)	Sex
		Male			Female
		X ± ∆m	M	90%	X ± ∆m	M	90%
Paraquat UAS-Gclc	7	76.6 ± 1.5	84	108	63.3 ± 1.7	60	96
	14	61.8 ± 1.6	60	84	42 ± 1.4	48	72
	21	48 ± 1.2	48	72	33 ± 1.4	36	60
	28	36.3 ± 1.1	36	60	24.5 ± 0.9	24	48
	35	24.6 ± 0.9	24	48	20.5 ± 0.7	24	48
	42	18.2 ± 0.6	24	48	17.9 ± 0.6	24	48
	49	17.5 ± 0.6	24	48	15 ± 0.5	24	48
	56	15.7 ± 0.5	24	48	13.8 ± 0.4	24	48
	63	12.8 ± 0.2	24	48	12.3 ± 0.2	24	48
Paraquat Appl-GAL4 > UAS-Gclc	7	80.3 ± 1.6	84	108	73.6 ± 1.8	72	108
	14	69.8 ± 1.6	72	96	78.2 ± 1.7	84	108
	21	60.4 ± 1.6	60	84	53.9 ± 1.6	60	84
	28	52.2 ± 1.3	48	72	43.2 ± 1.2	48	72
	35	33 ± 1.1	36	60	40.2 ± 1.1	48	72
	42	29.6 ± 1	36	60	29.4 ± 0.9	36	60
	49	22.6 ± 0.8	24	48	19.2 ± 0.7	24	48
	56	18.8 ± 0.6	24	48	19.7 ± 0.8	24	48
	63	16.6 ± 0.5	24	48	15 ± 0.5	24	48
	70	14 ± 0.4	24	48	13.6 ± 0.3	24	48
CuSO₄ UAS-Gclc	7	82 ± 1.4	84	108	87.3 ± 1.7	84	120
	14	70.2 ± 1.4	72	96	76.2 ± 2	72	108
	21	45.4 ± 1.9	48	72	60.1 ± 2.1	60	96
	28	46.8 ± 1.3	48	72	50.1 ± 1.9	48	84
	35	27 ± 1.1	24	48	46.7 ± 2	48	84
	42	31.5 ± 1	36	60	43.4 ± 1.4	48	72
	49	21 ± 0.9	24	48	29.2 ± 1.4	24	48
	56	20.7 ± 0.8	24	48	24.4 ± 1.1	24	48
	63	14.7 ± 0.4	24	48	20.6 ± 0.9	24	48
CuSO₄ Appl-GAL4 > UAS-Gclc	7	96.3 ± 1.2	96	120	107 ± 1.6	108	132
	14	78.3 ± 1.6	84	108	106 ± 1.9	108	132
	21	52.2 ± 1.4	48	72	93.9 ± 2.1	96	120
	28	53.8 ± 1.4	60	84	79.1 ± 2.2	72	120
	35	31.7 ± 1.3	36	60	60.6 ± 1.6	60	84
	42	32.2 ± 1	36	60	57.3 ± 1.9	60	84
	49	23.6 ± 1	24	48	52.2 ± 1.9	60	84
	56	25.7 ± 1	24	48	37.1 ± 1.6	36	72
	63	16.7 ± 0.6	24	48	28.3 ± 1.4	24	48
	70	14.5 ± 0.4	24	48	22.2 ± 1	24	48
CdCl₂ UAS-Gclc	7	67.6 ± 1.1	72	96	72.6 ± 2	72	108
	14	55.8 ± 1.1	60	84	63.8 ± 1.9	60	96
	21	31.6 ± 1	36	60	42.6 ± 1.8	36	72
	28	33 ± 1	36	60	43.5 ± 1.8	36	72
	35	21.9 ± 0.9	24	48	38.9 ± 1.6	36	60
	42	25 ± 0.9	24	48	32.5 ± 1.2	36	60
	49	16.2 ± 0.6	24	48	30.7 ± 1.5	24	60
	56	15.2 ± 0.5	24	48	20.4 ± 0.8	24	48
	63	12.8 ± 0.2	24	48	12.3 ± 0.2	24	48
CdCl₂ Appl-GAL4 > UAS-Gclc	7	71.9 ± 1.7	72	96	100.1 ± 1.7	96	132
	14	59.9 ± 1.2	60	84	91.8 ± 1.9	96	120
	21	39.5 ± 1.2	48	72	77 ± 1.7	84	108
	28	41.4 ± 1.1	48	72	69 ± 1.9	72	96
	35	27.1 ± 1	24	48	51 ± 1.4	48	72
	42	26.3 ± 0.8	36	60	44.7 ± 1.4	48	72
	49	19.2 ± 0.7	24	48	45.6 ± 1.3	48	72
	56	23.8 ± 0.7	24	48	30.7 ± 1.2	36	60
	63	16.8 ± 0.5	24	48	22.7 ± 0.9	24	48
	70	15.3 ± 0.5	24	48	19.1 ± 0.8	24	48
NaCl UAS-Gclc	7	96.2 ± 1.6	108	132	89.84	96	120
	14	65 ± 2	60	96	68.88	72	96
	21	63.2 ± 1.7	72	96	62.72	60	84
	28	57.6 ± 1.5	60	84	58.72	60	84
	35	34 ± 1.4	36	60	46.72	48	72
	42	30 ± 1.2	36	60	32	36	60
	49	19 ± 0.7	24	48	24.8	24	48
	56	15.4 ± 0.5	24	48	16.8	24	48
	63	12.4 ± 0.2	24	48	14.88	24	48
NaCl Appl-GAL4 > UAS-Gclc	7	85.1 ± 1.7	84	108	104.9 ± 1.8	108	132
	14	68 ± 2	72	96	85.6 ± 2.1	96	120
	21	61.8 ± 1.9	60	96	85.4 ± 1.8	96	120
	28	61 ± 1.8	60	84	86.6 ± 2.2	84	120
	35	41.6 ± 1.7	36	72	73.8 ± 1.9	72	108
	42	34.4 ± 1.1	36	60	56.6 ± 1.6	60	84
	49	20.7 ± 0.8	24	48	47 ± 1.5	48	72
	56	17.7 ± 0.6	24	48	27 ± 1.1	24	48
	63	15.2 ± 0.4	24	48	19 ± 0.8	24	48
	70	14.2 ± 0.4	24	48	14.1 ± 0.4	24	48

X ± ∆m - mean survival (h), M - median survival time (h), 90% - the time of 90% mortality (h)

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