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Table 3 Cox regression calculation results for Drosophila after exposure to different stress factors

From: The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions

Genotype

Factor

Parameter

Stresses

Paraquat

CuSO4

CdCl2

NaCl

Appl-GAL4 > UAS-Gclc

Sex

HR

1.026

0.5152

0.4533

0.4533

95% CI

0.9546-1.102

0.4783-0.555

0.4201-0.4891

0.4201-0.4891

UAS-Gclc

Age

HR

1.078

1.0681

1.0654

1.0824

95% CI

1.0757-1.0802

1.0661-1.0701

1.0634-1.0674

1.0800-1.0848

Sex

HR

1.5808

0.5105

0.4301

0.769

95% CI

1.4650-1.7057

0.4724-0.5516

0.3975-0.4655

0.7128-0.8297

Sex_male:

Appl-GAL4 > UAS-Gclc

HR

0.5333

0.7105 95

0.5943

0.7561

95% CI

0.4947-0.5749

0.6597-0.7651

0.5513-0.6407

0.7015-0.8150

Sex_female:

Appl-GAL4 > UAS-Gclc

HR

0.3558

0.3914

0.4064

0.3727

95% CI

0.3296-0.3841

0.3625-0.4226

0.3769-0.4383

0.3451-0.4025

  1. The first column shows the genotype compared flies in the analysis of the impact of these factors in the second column. HR - hazard ratio (the predicted risk of change when the value of the independent variable on the unit); 95% CI - a 95% confidence interval; Sex - a series of data showing the hazard regression for the flies with a certain genotype under the influence of each of the stress when factor is the individual’s sex; Age - a series of data showing the hazard regression for the flies with a certain genotype under the influence of each of the stress when factor is the individual’s age; Sex_male: Appl-GAL4 > UAS-Gclc a series of data showing the hazard ratio for flies with UAS-Gclc and Appl-GAL4 > UAS-Gclc genotypes when exposed to each of stresses, with the assessment of the impact of interacting factors (male sex, and genotype Appl-GAL4 > UAS-Gclc); Sex_female: Appl-GAL4 > UAS-Gclc a series of data showing the hazard ratio for flies with UAS-Gclc and Appl-GAL4 > UAS-Gclc genotypes when exposed to each of stresses, with the assessment of the impact of interacting factors (female sex, and genotype Appl-GAL4 > UAS-Gclc)