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Table 5 Key secondary metabolite genes found in the genome of P. subalpina

From: Globally distributed root endophyte Phialocephala subalpina links pathogenic and saprophytic lifestyles

Class Type Gene code SM clustera Length (aa) Domain structureb Remarks
NRPS-like L-alpha-aminoadipate reductase PAC_02750   1167 A-T-R Lys2, L-lysine biosynthesis
NRPS-like adenylating reductase PAC_02944 8 1049 A-T-R  
NRPS-like adenylating reductase PAC_01324 3 1047 A-T-R  
NRPS-like adenylating reductase PAC_02391 6 1023 A-T-R  
NRPS-like adenylating reductase PAC_03877 10 1117 A-T-R  
NRPS-like adenylating reductase PAC_04959 12 1038 A-T-R  
NRPS-like adenylating reductase PAC_05733   1008 A-T-R  
NRPS-like adenylating reductase PAC_07003   1054 A-T-R  
NRPS-like adenylating reductase PAC_12811   1054 A-T-R  
NRPS-like adenylating reductase PAC_17490   1065 A-T-R  
NRPS-like adenylating reductase PAC_19780   1050 A-T-R  
NRPS-like adenylating reductase PAC_02202 5 1227 A-T-R-Kinase  
NRPS-like adenylating reductase PAC_08842   1345 A-T-R-KR  
NRPS-like furanone synthetase PAC_08910 17 1013 A-T-TE  
NRPS-like quinone synthetase PAC_14584   979 A-T-TE  
NRPS-like unknown PAC_19640   1394 A-T-DUF  
NRPS-like unknown PAC_12359   1655 A-T-DUF  
NRPS   PAC_05248 13 4676 A-T-C-A-T-C-A-T-C-T-C-T-C Siderophore biosynthesis (Ferrichrome-like)
NRPS   PAC_13158   4838 A-T-C-A-T-C-T-C-A-T-C-T-C-T-C Siderophore biosynthesis (Ferrichrome-like)
NRPS   PAC_15746   1639 A-T-C-T-C  
NRPS   PAC_20134   4692 C-A-T-C-A-T-C-A-T-C-A-T-C-T  
NRPS   PAC_16560   565 A-T-C  
NRPS   PAC_16746   1207 A-T-C  
NRPS   PAC_19282   1220 A-T-C  
PKS-NRPS   PAC_02326   3974 KS-AT-DH-MT-KR-T-C-A-T-R  
PKS-NRPS   PAC_08246 16 3965 KS-AT-DH-MT-KR-T-C-A-T-R  
Type I PKS non-reducing PKS PAC_01338 4 2542 SAT-KS-AT-PT-T-MT-TE Citrinin biosynthesis-like
Type I PKS non-reducing PKS PAC_02435 7 2498 SAT-KS-AT-PT-T-MT-TE Citrinin biosynthesis-like
Type I PKS non-reducing PKS PAC_03302   2223 KS-AT-DH-T-TE  
Type I PKS non-reducing PKS PAC_03589 9 1670 KS-AT-PT-T-TE  
Type I PKS non-reducing PKS PAC_07895 15 2171 SAT-KS-AT-PT-T-T-TE Likely melanin biosynthesis
Type I PKS non-reducing PKS PAC_08751   2099 SAT-KS-AT-PT-T-T-TE  
Type I PKS non-reducing PKS PAC_10081   2125 SAT-KS-AT-PT-T-T-TE  
Type I PKS non-reducing PKS PAC_11435   2169 SAT-KS-AT-PT-T-T-TE Likely melanin biosynthesis
Type I PKS reducing PKS PAC_00199 1 2694 KS-AT-DH-MT-ER-KR-T Alternapyrone biosynthesis-like
Type I PKS reducing PKS PAC_00310 2 2283 KS-AT-DH-ER-KR-T  
Type I PKS reducing PKS PAC_01646   1687 AT-DH-MT-ER-KR-T  
Type I PKS reducing PKS PAC_04883 11 2239 KS-AT-DH-ER-KR-T  
Type I PKS reducing PKS PAC_06141   2258 KS-AT-DH-ER-KR-T  
Type I PKS reducing PKS PAC_10762   3173 KS-AT-DH-MT-ER-KR-T-Acyltransferase  
Type I PKS reducing PKS PAC_11350   3203 KS-AT-DH-MT-ER-KR-T-Acyltransferase  
Type I PKS reducing PKS PAC_14253   2590 KS-AT-DH-MT-ER-KR-T  
Type I PKS reducing PKS PAC_14645   2274 KS-AT-DH-ER-KR-T  
Type I PKS reducing PKS PAC_16276   3140 KS-AT-DH-MT-ER-KR-T-Acyltransferase  
Type I PKS reducing PKS PAC_17799   2411 KS-AT-DH-ER-KR-T Lovastatin-diketide synthase-like
Type I PKS reducing PKS PAC_19082   2581 KS-AT-DH-MT-ER-KR-T  
Type I PKS reducing PKS PAC_19990   2970 KS-AT-DH-MT-KR-T-C Lovastatin-nonaketide synthase-like
Type I PKS reducing PKS PAC_10712   1430 KS-AT-TH-KR-T 6-Methylsalicylate synthase-like PKS
Type III PKS   PAC_02116   479 IPR012328/IPR001099  
DMATS   PAC_15749   538 IPR017795  
Terpene   PAC_05884   483   
Terpene   PAC_13844   593 IPR017825/IPR017825/IPR002060 Squalene synthase-like
Terpene   PAC_15298   557   
Terpene   PAC_01018   338 IPR008949  
Terpene   PAC_04028   331 IPR008949  
Terpene   PAC_11164   466 IPR008949  
Terpene   PAC_12198   392 IPR008949  
Terpene   PAC_16221   336 IPR008949  
  1. a for details on the putative SM gene clusters see Additional file 3
  2. b Abbreviations for domains: A adenylation, AT acyltransferase, C condensation, DH dehydratase, DUF terminal NRPS domain of unknown function, ER enoyl reductase, KR ketoreductase, KS ketosynthase, MT methyltransferase, PT product template, R reduction, SAT starter unit-ACP-transacylase, T thiolation (=acyl- or aryl- or peptidylcarrier protein), TE thioesterase, TH thiohydrolase