Immune adaptation to chronic intense exercise training: new microarray evidence

BMC Genomics

Table 3 GO terms and KEGG pathways significantly enriched with genes showing higher transcript levels in blood leukocytes in athletes vs. controls

Name	No. of Genes	Odds Ratio	P Value	FDR
Cellular Oxidative Phosphorylation
KEGG: Huntington's disease	13	26.20	0.0001	0.0007
KEGG: Oxidative phosphorylation	13	7.93	0.0027	0.0037
KEGG: Alzheimer's disease	14	6.86	0.0029	0.0037
KEGG: Parkinson's disease	15	3.30	0.0139	0.0139
GO BP: generation of precursor metabolites and energy	14	4.95	0.0044	0.0227
Gene Translation
KEGG: Ribosome	27	5.19	0.0003	0.0008
GO BP: translation	47	2.69	0.0001	0.0073
GO BP: translational elongation	27	5.12	0.0001	0.0073
GO BP: RNA splicing	11	6.21	0.0058	0.0274
GO BP: RNA processing	25	2.30	0.0082	0.0329

Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) terms having false discovery rates (FDRs, significance statistic adjusted for multiple testing) of ≤0.05 from logistic regression-based method (LRpath analysis) are shown. No. Genes indicates how many analyzed genes belong to each enriched category; P value indicates significance of enrichment testing by LRpath analysis

ISSN: 1471-2164