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Table 4 GO terms significantly enriched with genes showing lower transcript levels in blood leukocytes in athletes vs. controls

From: Immune adaptation to chronic intense exercise training: new microarray evidence

Name

No. of Genes

Odds Ratio

P value

FDR

Response to stimuli (immune responses)

response to biotic stimulus

25

0.43

0.0002

0.0073

response to organic substance

29

0.43

0.0001

0.0073

regulation of developmental process

19

0.39

0.0003

0.0073

response to other organism

23

0.43

0.0003

0.0073

response to external stimulus

30

0.52

0.0010

0.0124

response to endogenous stimulus

18

0.41

0.0010

0.0124

multi-organism process

40

0.58

0.0022

0.0162

reproductive process

16

0.38

0.0009

0.0124

blood vessel development

11

0.35

0.0034

0.0187

response to wounding

31

0.56

0.0034

0.0187

myeloid cell differentiation

11

0.38

0.0055

0.0274

defense response

32

0.59

0.0062

0.0279

response to virus

12

0.41

0.0063

0.0279

hemopoiesis

18

0.50

0.0067

0.0279

regulation of cell proliferation

21

0.47

0.0016

0.0157

regulation of cell differentiation

14

0.38

0.0018

0.0157

response to extracellular stimulus

11

0.42

0.0095

0.0366

leukocyte differentiation

10

0.42

0.0138

0.0492

positive regulation of cell proliferation

14

0.49

0.0142

0.0492

cellular response to chemical stimulus

16

0.52

0.0142

0.0492

regulation of multicellular organismal development

16

0.38

0.0008

0.0124

negative regulation of developmental process

10

0.34

0.0044

0.0227

response to hormone stimulus

16

0.41

0.0017

0.0157

response to steroid hormone stimulus

10

0.38

0.0078

0.0320

homeostatic process

24

0.50

0.0021

0.0162

Regulation of Apoptosis

negative regulation of apoptosis

17

0.35

0.0003

0.0073

regulation of apoptosis

24

0.49

0.0014

0.0148

anti-apoptosis

11

0.31

0.0020

0.0162

transcription

transcription from RNA polymerase II promoter

20

0.42

0.0006

0.0119

regulation of transcription from RNA polymerase II promoter

18

0.45

0.0022

0.0162

negative regulation of transcription

10

0.31

0.0031

0.0187

Regulation of cellular metabolic process

positive regulation of cellular metabolic process

23

0.46

0.0009

0.0124

positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

12

0.34

0.0020

0.0162

negative regulation of macromolecule biosynthetic process

12

0.37

0.0032

0.0187

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

10

0.31

0.0031

0.0187

positive regulation of nitrogen compound metabolic process

13

0.39

0.0028

0.0187

positive regulation of cellular biosynthetic process

14

0.44

0.0058

0.0274

positive regulation of RNA metabolic process

10

0.40

0.0099

0.0373

positive regulation of multicellular organismal process

10

0.41

0.0122

0.0453

negative regulation of cellular metabolic process

20

0.55

0.0139

0.0492

  1. Gene Ontology (GO) terms having false discovery rates (FDRs, significance statistic adjusted for multiple testing) of ≤0.05 from logistic regression-based method (LRpath analysis) are shown. No. of Genes indicates how many analyzed genes belong to each enriched category. P value indicates significance of enrichment testing by LRpath analysis