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Table 4 GO terms significantly enriched with genes showing lower transcript levels in blood leukocytes in athletes vs. controls

From: Immune adaptation to chronic intense exercise training: new microarray evidence

Name No. of Genes Odds Ratio P value FDR
Response to stimuli (immune responses)
response to biotic stimulus 25 0.43 0.0002 0.0073
response to organic substance 29 0.43 0.0001 0.0073
regulation of developmental process 19 0.39 0.0003 0.0073
response to other organism 23 0.43 0.0003 0.0073
response to external stimulus 30 0.52 0.0010 0.0124
response to endogenous stimulus 18 0.41 0.0010 0.0124
multi-organism process 40 0.58 0.0022 0.0162
reproductive process 16 0.38 0.0009 0.0124
blood vessel development 11 0.35 0.0034 0.0187
response to wounding 31 0.56 0.0034 0.0187
myeloid cell differentiation 11 0.38 0.0055 0.0274
defense response 32 0.59 0.0062 0.0279
response to virus 12 0.41 0.0063 0.0279
hemopoiesis 18 0.50 0.0067 0.0279
regulation of cell proliferation 21 0.47 0.0016 0.0157
regulation of cell differentiation 14 0.38 0.0018 0.0157
response to extracellular stimulus 11 0.42 0.0095 0.0366
leukocyte differentiation 10 0.42 0.0138 0.0492
positive regulation of cell proliferation 14 0.49 0.0142 0.0492
cellular response to chemical stimulus 16 0.52 0.0142 0.0492
regulation of multicellular organismal development 16 0.38 0.0008 0.0124
negative regulation of developmental process 10 0.34 0.0044 0.0227
response to hormone stimulus 16 0.41 0.0017 0.0157
response to steroid hormone stimulus 10 0.38 0.0078 0.0320
homeostatic process 24 0.50 0.0021 0.0162
Regulation of Apoptosis
negative regulation of apoptosis 17 0.35 0.0003 0.0073
regulation of apoptosis 24 0.49 0.0014 0.0148
anti-apoptosis 11 0.31 0.0020 0.0162
transcription
transcription from RNA polymerase II promoter 20 0.42 0.0006 0.0119
regulation of transcription from RNA polymerase II promoter 18 0.45 0.0022 0.0162
negative regulation of transcription 10 0.31 0.0031 0.0187
Regulation of cellular metabolic process
positive regulation of cellular metabolic process 23 0.46 0.0009 0.0124
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 12 0.34 0.0020 0.0162
negative regulation of macromolecule biosynthetic process 12 0.37 0.0032 0.0187
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 10 0.31 0.0031 0.0187
positive regulation of nitrogen compound metabolic process 13 0.39 0.0028 0.0187
positive regulation of cellular biosynthetic process 14 0.44 0.0058 0.0274
positive regulation of RNA metabolic process 10 0.40 0.0099 0.0373
positive regulation of multicellular organismal process 10 0.41 0.0122 0.0453
negative regulation of cellular metabolic process 20 0.55 0.0139 0.0492
  1. Gene Ontology (GO) terms having false discovery rates (FDRs, significance statistic adjusted for multiple testing) of ≤0.05 from logistic regression-based method (LRpath analysis) are shown. No. of Genes indicates how many analyzed genes belong to each enriched category. P value indicates significance of enrichment testing by LRpath analysis