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Table 2 Selected group of genes characteristic for nude mice

From: Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing

Gene

Gene name

Epidermis

Skin

nude vs B6

nude vs B6

up

down

up

down

Wisp2

WNT1 inducible signaling pathway protein 2

  

13.46

 

Wnt10a

Wingless related MMTV integration site 10a

  

4.64

 

Wnt11

Wingless-related MMTV integration site 11

3.38

 

2.48

 

Wnt7a

Wingless-related MMTV integration site 7A

   

5.63

Fzd1

Frizzled homolog 1 (Drosophila)

  

2.18

 

Fzd6

Frizzled homolog 6 (Drosophila)

  

2.02

 

Frzb

Frizzled-related protein

   

5.08

Sfrp2

Secreted frizzled-related protein 2

   

2.38

Ctnnb1

Catenin (cadherin associated protein), beta 1

4.9

   

Ctnnbl1

Catenin, beta like 1

   

2.26

Dkk1

Dickkopf homolog 1 (Xenopus laevis)

   

8.22

Dlk1

Delta-like 1 homolog (Drosophila)

   

9.01

Dll4

Dll-4 mRNA for Delta-4

   

3.18

Dll1 a

Delta-like 1 (Drosophila)

 

2.7

 

2.33

Notch2

Notch2

 

2.36

  

Notch4

Notch gene homolog 4 (Drosophila)

   

2.48

Hes5

Hairy and enhancer of split 5 (Drosophila)

   

10.26

Hes6 a

Hairy and enhancer of split 6 (Drosophila)

   

8.41

Hey1

Brain cDNA, clone MNCb-2686, similar to Mus musculus hairy/enhancer-of-split related with YRPW motif1

   

3.39

Hey2

HES-related repressor protein 1 HERP1

   

2.39

Bmp2

Bone morphogenetic protein 2

 

2.4

 

3.55

Bmp4

Bone morphogenetic protein 4

 

3.23

  

Bmpr1b

Bone morphogenetic protein receptor, type 1B

   

2.75

Smad1

MAD homolog 1 (Drosophila)

   

2.56

Mmp-12

Matrix metallopeptidase 12

3.89

 

64.36

 

Mmp-3

Matrix metallopeptidase 3

  

21.83

 

Mmp-13

Matrix metallopeptidase 13

  

5.46

 

Mmp-8

Matrix metallopeptidase 8

  

4.71

 

Timp1

Tissue inhibitor of metalloproteinase 1

  

3.58

 

Mmp-9

Matrix metallopeptidase 9

 

2.22

3.28

 

Mmp-2

Matrix metallopeptidase 2

2.21

 

3.02

 
  1. aGenes that are down regulated in E14 skin (see Table S2)