Cecal MicroRNAome response to Salmonella enterica serovar Enteritidis infection in White Leghorn Layer

BMC Genomics

Table 3 The significantly enriched pathways in three groups of target genes (P < 0.05)

	Pathway	No. of genes	P value	Fold enrichment	Genes
G1	Endocytosis	18	0.040	1.65	CHMP2A, HRAS, CLTC, CHMP2B, EPS15, SMAP2, AP2A2, TFRC, RABEP1, CXCR4, WWP1, NTRK1, MDM2, IL2RG, PDCD6IP, EGF, EHD3, AP2M1
G2	ECM-receptor interaction	10	0.007	2.86	CD47, COL4A2, ITGA8, ITGAV, COL6A3, ITGA3, VTN, SDC2, SDC3, SPP1
	Glycolysis/Gluconeogenesis	7	0.017	3.32	LDHB, GPI, TPI1, LDHA, PGM1, DLD, PGAM1
	Focal adhesion	16	0.018	1.91	COL4A2, MAP2K1, ACTN1, ITGA3, VTN, PPP1CC, CDC42, CCND1, ITGA8, ITGAV, COL6A3, ILK, RHOA, MAPK9, FIGF, SPP1
	Melanogenesis	10	0.020	2.43	WNT5A, KRAS, MAP2K1, CALM, MAP2K2, ADCY5, FZD1, CAMK2D, WNT6, FZD7
	Proteasome	6	0.024	3.53	PSMC3, PSMA4, PSMC2, PSMD3, PSME3, PSMD4
G3	Cell cycle	27	3.68E-04	2.04	E2F1, YWHAZ, E2F4, E2F5, ANAPC10, CIP1, CDKN2B, TFDP2, BUB1, CCNA2, RBL2, YWHAB, SKP2, RB1, SKP1, CDC27, MCM5, ATM, CDC25A, WEE1, CDK3, YWHAG, YWHAH, CCND3, HDAC1, PLK1, YWHAQ
G3	SNARE interactions in vesicular transport	9	0.041	2.21	STX6, STX17, USE1, BET1L, SEC22B, VAMP3, GOSR2, SNAP23, GOSR1

Note: G1 means the unique target genes of up-regulated miRNAs, G2 means the unique target genes of down-regulated miRNAs, G3 means the target genes regulated by both up and down-regulated miRNAs

ISSN: 1471-2164