Skip to main content

Advertisement

Table 1 DE gene pathways in HuNoV NS1-2 and NS1-2 dis transfected cells

From: Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes

  NS1-2 gene counts NS1-2 dis gene counts NS1-2 aadjusted p-values NS1-2 disaadjusted p-values
Upregulated gene pathways
 Proteasome 25 15 1.80E−15 2.30E−06
 Aminoacyl-tRNA biosynthesis 14 9 4.80E−05 2.30E−02
 Focal adhesion 27 22 6.90E−03 2.60E−02
 RIG-I-like receptor signaling 14 10 5.60E−03 6.20E−02
 Toll-like receptor signaling 16 13 2.10E−02 5.30E−02
 Pathways in cancer 33 28 7.80E−02 4.80E−02
 NOD-like receptor signaling 11 8 7.20E−02 1.90E−01
 Apoptosis 12 11 1.90E−01 9.50E−02
 Regulation of actin cytoskeleton 22 16 1.80E−01 3.80E−01
 Antigen processing and presentation 11 9 3.00E−01 3.50E−01
 MAPK signaling 24 22 3.00E−01 1.50E−01
 Gap junction 10 10 3.60E−01 1.90E−01
 VEGF signaling 9 9 3.80E−01 1.90E−01
 Cytokine-cytokine receptor interaction - 20 - 1.80E−01
Downregulated gene pathways
 Lysosome 28 17 1.50E−11 4.30E−05
 Leukocyte transendothelial migration 13 8 2.00E−01 6.30E−01
 Phosphatidylinositol signaling system 9 9 3.30E−01 1.00E−01
 Toll-like receptor signaling 10 7 3.70E−01 5.80E−01
 Regulation of actin cytoskeleton 16 12 4.30E−01 7.30E−01
 Glycosaminoglycan degradation 4 4 6.60E−01 7.50E−01
 Cell adhesion molecules 11 - 7.10E−01 -
 p53 signaling - 6 - 8.50E−01
 Cytokine-cytokine receptor interaction - 13 - 6.80E−01
 Focal adhesion - 11 - 5.90E−01
 mTOR signaling - 5 - 5.40E−01
  1. aadjusted p-values calculated using the Benjamini-Hochberg procedure