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Table 1 DE gene pathways in HuNoV NS1-2 and NS1-2 dis transfected cells

From: Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes

 

NS1-2 gene counts

NS1-2 dis gene counts

NS1-2 aadjusted p-values

NS1-2 disaadjusted p-values

Upregulated gene pathways

 Proteasome

25

15

1.80E−15

2.30E−06

 Aminoacyl-tRNA biosynthesis

14

9

4.80E−05

2.30E−02

 Focal adhesion

27

22

6.90E−03

2.60E−02

 RIG-I-like receptor signaling

14

10

5.60E−03

6.20E−02

 Toll-like receptor signaling

16

13

2.10E−02

5.30E−02

 Pathways in cancer

33

28

7.80E−02

4.80E−02

 NOD-like receptor signaling

11

8

7.20E−02

1.90E−01

 Apoptosis

12

11

1.90E−01

9.50E−02

 Regulation of actin cytoskeleton

22

16

1.80E−01

3.80E−01

 Antigen processing and presentation

11

9

3.00E−01

3.50E−01

 MAPK signaling

24

22

3.00E−01

1.50E−01

 Gap junction

10

10

3.60E−01

1.90E−01

 VEGF signaling

9

9

3.80E−01

1.90E−01

 Cytokine-cytokine receptor interaction

-

20

-

1.80E−01

Downregulated gene pathways

 Lysosome

28

17

1.50E−11

4.30E−05

 Leukocyte transendothelial migration

13

8

2.00E−01

6.30E−01

 Phosphatidylinositol signaling system

9

9

3.30E−01

1.00E−01

 Toll-like receptor signaling

10

7

3.70E−01

5.80E−01

 Regulation of actin cytoskeleton

16

12

4.30E−01

7.30E−01

 Glycosaminoglycan degradation

4

4

6.60E−01

7.50E−01

 Cell adhesion molecules

11

-

7.10E−01

-

 p53 signaling

-

6

-

8.50E−01

 Cytokine-cytokine receptor interaction

-

13

-

6.80E−01

 Focal adhesion

-

11

-

5.90E−01

 mTOR signaling

-

5

-

5.40E−01

  1. aadjusted p-values calculated using the Benjamini-Hochberg procedure