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Table 3 Top 50 regions in terms of combined score identified by our method. We give the position of the region, number of genomes that are mutated within the region, the combined score, and a classification of the region based annotations and our method of identifying hypermutated regions. We also manually annotated each region by viewing in the UCSC genome browser

From: Identification of coding and non-coding mutational hotspots in cancer genomes

rank chr Start End Mutated samples Score Automated annotation Manual annotation
1 chr12 25398250 25398300 256 208.4 driver KRAS exon
2 chr17 7577100 7577150 68 98.1 driver TP53 exon
3 chr17 7577500 7577550 62 89.1 driver TP53 exon
4 chr3 41266100 41266150 65 84.0 driver CTNNB1 exon
5 chr17 7578400 7578450 50 72.0 driver TP53 exon
6 chr17 7577550 7577600 41 57.5 driver TP53 exon
7 chr17 7578250 7578300 31 46.1 driver TP53 exon
8 chr17 7578200 7578250 32 45.8 driver TP53 exon
9 chr17 7577050 7577100 29 40.9 driver TP53 exon
10 chr17 7578500 7578550 26 38.6 driver TP53 exon
11 chr10 96652800 96652850 14 30.1 hotspot Non-coding
12 chr12 6899300 6899350 3 28.6 hotspot CD4 intron
13 chr17 7578450 7578500 18 26.4 driver TP53 exon
14 chr17 7578350 7578400 17 25.5 driver TP53 exon
15 chr17 7574000 7574050 19 25.4 driver TP53 exon
16 chr17 7578550 7578600 13 23.3 driver TP53 exon
17 chr17 7577000 7577050 14 22.6 driver TP53 exon
18 chr17 7578150 7578200 13 22.5 driver TP53 exon
19 chr21 44524450 44524500 9 20.9 driver TP53 exon
20 chr3 41266050 41266100 10 20.2 driver CTNNB1 exon
21 chr3 195892250 195892300 18 19.5 non-coding Non-coding
22 chr9 21971100 21971150 12 17.9 driver CDKN2A exon
23 chr12 64749950 64750000 7 17.7 hotspot C12orf56 intron
24 chr17 7579300 7579350 10 16.8 driver TP53 exon
25 chr2 198266800 198266850 9 16.8 driver SF3B1 exon
26 chr12 25380250 25380300 20 16.8 driver KRAS exon
27 chr18 48591900 48591950 11 16.8 driver SMAD4 exon
28 chr3 178936050 178936100 9 16.7 driver PIK3CA exon
29 chr11 63881800 63881850 9 16.3 hotspot FLRT1 intron
30 chr13 50016900 50016950 8 16.0 hotspot CAB39L intron
31 chr19 11134250 11134300 6 15.7 driver SMARCA4 exon
32 chr15 64857000 64857050 9 15.5 hotspot ZNF609 intron
33 chr20 57484400 57484450 13 15.5 driver GNAS exon
34 chr16 3786700 3786750 5 15.4 driver CREBBP exon
35 chr17 17424850 17424900 7 14.9 hotspot PEMT intron
36 chr14 24895100 24895150 11 14.7 hotspot Non-coding / TF binding
37 chr18 48575150 48575200 7 14.7 driver SMAD4 exon
38 chr18 48604750 48604800 7 14.6 driver SMAD4 exon
39 chr19 11132500 11132550 5 14.6 driver SMARCA4 exon
40 chr17 79389900 79389950 9 14.3 hotspot BAHCC1 exon
41 chr18 48591800 48591850 8 14.2 driver SMAD4 exon
42 chr3 178952050 178952100 7 14.2 driver PIK3CA exon
43 chr7 76949650 76949700 6 14.0 hotspot GSAP intron
44 chr14 74239050 74239100 8 13.9 hotspot ELMSAN1 intron
45 chr17 56408600 56408650 5 13.9 non-coding MIR142 non-coding
46 chr22 46697350 46697400 5 13.6 hotspot GTSE1 intron
47 chr8 30717550 30717600 7 13.4 hotspot TEX15 exon-intron border
48 chr10 89692900 89692950 3 13.3 driver PTEN exon
49 chr17 7577600 7577650 5 13.3 driver TP53 splice site
50 chr4 819750 819800 6 13.2 hotspot CPLX1 intron