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Fig. 2 | BMC Genomics

Fig. 2

From: Modular combinatorial binding among human trans-acting factors reveals direct and indirect factor binding

Fig. 2

Trans-acting factors bind in a complex combinatorial and context-specific manner. RMD was applied to a compendium of ChIP-seq binding sites of 115 TFs (~140,000 regions) in human K562 cells and discovered 49 modules. Each cell in the heatmap represents the z-score of the TF binding site count (standardized along the columns) of a TF (column) in a module (row). The bottom bar plot shows the total number of binding sites of the TFs. The right bar plot shows the number of regions that use the modules. The top and left dendrograms were computed by applying hierarchical clustering on the regulatory module matrix with Pearson correlation distance and average linkage. The module and TF labels are colored according to the hierarchical clusters. Selected groups of similar modules are labelled based on the major TFs participating in each module

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