Table 1 Summary of TCDD Datasets
From: Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems
Species | Tissue | Strain/AHR Genotype | Sex | Number of Samples | Dose(s) (μg/kg) | Time(s) (hours) | GEO Accession |
|---|---|---|---|---|---|---|---|
Human | adipose-derived stem cells | hWT | N/A | 8 | 25nM | 48 | GSE32026 |
primary hepatocyte cell line | hWT | male and female | 3 | 0.00001, 0.001, 0.01, 0.1, 1, 10, 316 (nM) | 48 | GSE14555 | |
Mouse | kidney | C57BL/6 | male | 12 | 0, 1000 | 19 | GSE15857 |
AHR-KO | male | 6 | |||||
liver | C57BL/6 | male | 62 | 0, 125, 250, 500, 1000 | 6, 19, 24, 72, 96, 144 | GSE15858 GSE61037 GSE61038 | |
female | 47 | 6, 24, 72, 96, 144 | GSE61037 GSE61038 | ||||
DBA/2 | male | 12 | 0, 5, 500 | 19 | NA | ||
AHR-KO | male | 6 | 0, 1000 | 19 | GSE15858 | ||
rWT (L-E) | male | 17 | 0, 125, 250, 500, 1000 | 96 | GSE72270 | ||
DEL (H/W) | male | 21 | |||||
INS (H/W) | male | 22 | |||||
Rat | adipose | L-E | male | 20 | 0, 100 | 24, 96 | GSE18301 |
H/W | male | 8 | 24 | ||||
hypothalamus | L-E | male | 7 | 23 | GSE61039 | ||
H/W | male | 8 | |||||
liver | L-E | male | 39 | 3, 19, 96, 240 | GSE10083 GSE13513 | ||
H/W | male | 30 | |||||
Ln-A (H/W) | male | 8 | 19 | GSE10083 | |||
Ln-C (L-E) | male | 8 | |||||
primary hepatocyte cell line | rWT (SD) | female | 14 | 0.00001, 0.001, 0.01, 0.1, 1, 10, 316 (nM) | 48 | GSE14555 |