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Table 2 A partial list of the GO analysis results of target genes predicted by two different putative complexes using the K562 USF2 ChIP-seq data

From: Inferring condition-specific targets of human TF-TF complexes using ChIP-seq data

Rank

Enrichment GO term

p-value

Predicted USF2-IRF1 complexa

1

GO:0032870 cellular response to hormone stimulus

2.15E-07

2

GO:0033572 transferrin transport

7.16E-07

3

GO:0015682 ferric iron transport

7.16E-07

4

GO:0071495 cellular response to endogenous stimulus

1.20E-06

5

GO:0071375 cellular response to peptide hormone stimulus

1.55E-06

6

GO:0015031 protein transport

2.94E-06

7

GO:0044437 vacuolar part

3.21E-06

8

GO:0005654 nucleoplasm

3.82E-06

9

GO:0043434 response to peptide hormone stimulus

7.11E-06

10

GO:0006826 iron ion transport

7.92E-06

Predicted USF2-NFYA complexb

1

GO:0004536 deoxyribonuclease activity

1.53E-04

2

GO:0016798 hydrolase activity, acting on glycosyl bonds

2.58E-04

3

GO:0019104 DNA N-glycosylase activity

3.79E-04

4

GO:0006886 intracellular protein transport

5.00E-04

5

GO:0044419 interspecies interaction between organisms

5.43E-04

6

GO:0006308 DNA catabolic process

6.97E-04

7

GO:0044265 cellular macromolecule catabolic process

7.91E-04

8

GO:0016799 hydrolase activity, hydrolysing N-glycosyl compounds

1.16E-03

9

GO:0060674 placenta blood vessel development

1.29E-03

10

GO:0032507 maintenance of protein location in cell

1.42E-03

  1. aGO enrichment results for targets of the predicted USF2-IRF1 complex. The second, third and tenth GO terms are related to iron transport. A previous study reported that USF2 and IRF1 co-regulate β2-microglobulin, which regulates iron metabolism and transport
  2. bGO enrichment results for targets of the predicted USF2-NFYA complex. The top ten GO term results are associated with DNA catabolism and clearly differed from the results of the predicted USF2-IRF1 complex