Fig. 2
From: The emerging landscape of dynamic DNA methylation in early childhood
Molecular enrichment of a-DMSs for regulatory features. Fold enrichment of 9,704 da-DMSs (blue bar) and 4,446 ia-DMSs (grey bar). a CpG islands, shore, shelf and open sea. b Gene regions including: within 1.5 kb upstream of the transcription start site (TSS1500), the 5' untranslated region (5′UTR), the first gene exon, the gene body, the 3' UTR or intergenic region. c Predicted gene expression regulatory regions based on histone modifications derived from Roadmap epigenomics blood data. d Predicted chromatin state based on Roadmap epigenomics blood data. DNase: DNase I hypersensitive site, Enh: Enhancers, EnhBiv: Bivalent enhancer, TssA: Active TSS, TSSBiv: Bivalent/poised TSS, Tx: Strong transcription, TxWk: Weak transcription. The presented fold enrichments are from 1,264 samples by χ 2 test and are relative to all 437,792 CpG sites tested (y-axis); * 1 × 10−3 ≤ P < 0.01, ** 1 × 10−6 ≤ P < 1 × 10-3, *** P < 1 × 10−6