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Fig. 3 | BMC Genomics

Fig. 3

From: The emerging landscape of dynamic DNA methylation in early childhood

Fig. 3

Genetic variation associated with longitudinal DNA methylation changes by cis-dMeQTL study. a The effect sizes of MeQTL at age 4 years against those at age 8 years of 3421 SNP-CpG pairs in the age 4-8 group. Almost all the dots lie in the first and third quadrants, suggesting that the effect size of genetic factors on methylation from most of the SNP-CpG pairs followed the same direction at both ages. Blue dots represent SNP-CpG pairs with a significantly weaker effect size at age 4 than at age 8, whereas green dots represent a stronger effect, and red dots represent a different direction of effect. b Bar plot of 3421 SNP-CpG pairs. There are 725 SNP-CpG pairs showing a weaker effect at age 4 than age 8 (blue bar), 3,348 SNP-CpG pairs showing stronger effect (green bar) and 73 SNP-CpG pairs showing a different effect (red bar). c Boxplot of dMeQTL of rs9320331-cg00074818. 181 PIAMA samples have been used to illustrate this dMeQTL. d Regional dMeQTL association of cg00074818 results for the age 4–8 group. Plots were generated using LocusZoom [48]. The LD estimates are color-coded as a heatmap from dark blue (0 ≥ r 2 > 0.2) to red (0.8 ≥ r 2 > 1.0) Regional plot shows-log10 P of all SNPs surrounding SNP rs9320331, and the degree of linkage disequilibrium between all SNPs and lead SNP rs9320331. SNPs with lower P-values span DDO and SLC22A18 genes within a recombination boundary. e Boxplot of MeQTL of rs9320331-cg00074818 at age 4 and age 8 cross-sectionally

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