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Fig. 5 | BMC Genomics

Fig. 5

From: Enumerateblood – an R package to estimate the cellular composition of whole blood from Affymetrix Gene ST gene expression profiles

Fig. 5

Our model identifies better performing marker genes for use with reference-free approaches in Affymetrix Gene ST data. Surrogate proportion variables obtained from CellCODE are plotted against the cell proportions obtained from CBC/Diffs in an independent dataset (CHFP cohort). The sum of the surrogate proportion variables obtained for B, CD4+ T, CD8+ T and NK cells is compared to the total lymphocyte proportions from the CBC/Diffs. Marker genes used by CellCODE were derived from the coefficients of the model (a) or using the recommended set of marker genes (b) derived from the IRIS reference dataset. For each cell type, Spearman’s rank correlation (ρ) is reported

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BMC Genomics

ISSN: 1471-2164

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