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Fig. 2 | BMC Genomics

Fig. 2

From: Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes

Fig. 2

Function of a SNP contained within a VDR binding peak associated with Toll-like receptor 1 (TLR1). The top panel shows the presence of rs5743565 (blocked out), which is in LD with rs2101521 (orange arrow) associated with self-reported allergy in GWAS study. VDR peaks are shown as Red block custom tracts. The rs5743565 is associated with expression of the genes TLR10, TLR6 and TLR1. The bottom panel shows the ENCODE ChIP-seq data for binding of different transcription factors in the region harboring rs5743565 and VDR binding sites (in red). The presence of rs5743565 in the binding region is predicted to alter the association of multiple transcription factors and the expression of associated genes, and therefore been assigned a score in RegulomeDB of < = 2

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BMC Genomics

ISSN: 1471-2164

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