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Table 7 Most frequent miRNAs in pairs and triples

From: A clustering-based approach for efficient identification of microRNA combinatorial biomarkers

MiRNA name PMID Description
hsa-mir-18a 16754881 Copy number loss
  19684618 Higher levels of expression in ERalpha-negative tumors
  19624877 Differentially expressed between breast cancer cells and mammary epithelial cells, highly expressed in MCF-7 cells
  21755340 Expression was much higher in ERa-negative than in ERa-positive tumors.
hsa-mir-146b 16461460 Overexpressed
  19190326 miR-146: Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis
  18634034 miR-146: rs2910164 were associated with increased risk of breast cancer in Chinese women
  21409395 miR-146b-5p preferentially expressed in normal basal cells
  21472990 Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers.
hsa-mir-149 18634034 miR-149: rs2292832 were associated with increased risk of breast cancer in Chinese women
hsa-mir-224 21953071 Down-regulated during lobular neoplasia progression compared to normal epithelium.
  22809510 MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells.
hsa-mir-452 22353773 Differentially expressed between serum samples from patients with cancer and serum samples from healthy controls
hsa-miR-365 18812439 Up-regulated greater than 2-fold in BC compared with NAT, potential target genes include members of RAS oncogenes.
hsa-mir-340 21225860 Inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met
  21692045 Inhibites breast cancer cell migration and invasion through targeting of oncoprotein c-Met.
hsa-mir-100 21634028 Regulates beta-tubulin isotypes in MCF7 breast cancer cells.
  22926517 Suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling.
hsa-mir-141 18376396 Downregulated
  22952344 CTC (circulating tumour cells)-positive had significantly higher levels of miR-141 than CTC-negative MBC and controls.