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Table 7 Most frequent miRNAs in pairs and triples

From: A clustering-based approach for efficient identification of microRNA combinatorial biomarkers

MiRNA name

PMID

Description

hsa-mir-18a

16754881

Copy number loss

 

19684618

Higher levels of expression in ERalpha-negative tumors

 

19624877

Differentially expressed between breast cancer cells and mammary epithelial cells, highly expressed in MCF-7 cells

 

21755340

Expression was much higher in ERa-negative than in ERa-positive tumors.

hsa-mir-146b

16461460

Overexpressed

 

19190326

miR-146: Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis

 

18634034

miR-146: rs2910164 were associated with increased risk of breast cancer in Chinese women

 

21409395

miR-146b-5p preferentially expressed in normal basal cells

 

21472990

Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers.

hsa-mir-149

18634034

miR-149: rs2292832 were associated with increased risk of breast cancer in Chinese women

hsa-mir-224

21953071

Down-regulated during lobular neoplasia progression compared to normal epithelium.

 

22809510

MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells.

hsa-mir-452

22353773

Differentially expressed between serum samples from patients with cancer and serum samples from healthy controls

hsa-miR-365

18812439

Up-regulated greater than 2-fold in BC compared with NAT, potential target genes include members of RAS oncogenes.

hsa-mir-340

21225860

Inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met

 

21692045

Inhibites breast cancer cell migration and invasion through targeting of oncoprotein c-Met.

hsa-mir-100

21634028

Regulates beta-tubulin isotypes in MCF7 breast cancer cells.

 

22926517

Suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling.

hsa-mir-141

18376396

Downregulated

 

22952344

CTC (circulating tumour cells)-positive had significantly higher levels of miR-141 than CTC-negative MBC and controls.