From: An integrated approach with new strategies for QSAR models and lead optimization
Selected residue | Descriptions |
---|---|
TYR72 | Stabilize ligand ring |
TRP86 | Forming π-π interaction to stabilize ligand |
ASN87 | Electrostatic contributors in the gorge area |
TYR124 | Form hydrophobic contacts with ligand |
SER203 | Catalytic triad |
TRP286 | Enhance the activity of ligand with polar groups |
TYR337 | Electrostatic contributors in the gorge area |
PHE338 | Form hydrophobic contacts with ligand |
TYR341 | The residue in the local pocket |
HIS447 | Catalytic triad |