Fig. 5

Network analysis of key transcriptional factors (TFs) in VL-blood pathology. The VL-blood DEGs list was analyzed using the “transcriptional regulation network” algorithm (see Additional file 9: Table S6). Auto-expanded (by one step) network was generated using the top three (CREB1, MYC and IRF4) TFs associated with disease-related BPs and then merged. STAT1 and NF-kB (from the dataset- orange boxes) as well as CREB1, MYC, IRF4, (“hidden” from dataset- yellow boxes) are TF hubs revealing a large number of curated interactions directly to and from (direction of arrow) objects in the VL-blood profile. Each hub is color coded (red = IRF4, blue = MYC, green = CREB1, magenta = STAT1/IRF9/ISG15 complex, variable colors = NF-kB (connected to several hubs). See Fig. 4 legend for types of objects