HAPPI-2: a Comprehensive and High-quality Map of Human Annotated and Predicted Protein Interactions

BMC Genomics

Table 3 Calculated spearman’s rank correlation of PPIs among hub proteins found in common of each pair of human PPI databases under evaluation

	HAPPI-2’	HAPPI-2	HAPPI-1’	HAPPI-1	HPRD	I2d	IntNetDB	Wang	BioGRID	STRING
HAPPI-2’	1.00	0.28	0.19	−0.20	−0.07	0.57	0.23	0.05	0.65	0.19
HAPPI-2		1.00	0.42	0.40	0.06	0.41	0.50	0.01	0.02	0.77
HAPPI-1’			1.00	0.51	−0.12	−0.32	0.60	0.20	0.03	−0.11
HAPPI-1				1.00	−0.24	−0.60	0.50	−0.45	−0.21	−0.54
HPRD					1.00	0.25	0.00	0.26	−0.06	0.55
I2d						1.00	−0.60	−0.32	0.56	0.49
IntNetDB							1.00	0.00	−1.00	0.00
Wang								1.00	0.18	0.14
BioGRID									1.00	0.12
STRING										1.00

The Spearman’s correlation coefficient is calculated by comparing the rankings of network degrees of connectivity among top-100 highly connected HAPPI-2 human proteins in each pair of databases under comparison. HAPPI-2’ and HAPPI-1’ refers to the medium- to ultrahigh-confidence subsets of the HAPPI-2 and HAPPI-1 database respectively. The pairs of databases with high (>0.25) correlation coefficients are bolded

ISSN: 1471-2164