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Table 3 Calculated spearman’s rank correlation of PPIs among hub proteins found in common of each pair of human PPI databases under evaluation

From: HAPPI-2: a Comprehensive and High-quality Map of Human Annotated and Predicted Protein Interactions

  HAPPI-2’ HAPPI-2 HAPPI-1’ HAPPI-1 HPRD I2d IntNetDB Wang BioGRID STRING
HAPPI-2’ 1.00 0.28 0.19 −0.20 −0.07 0.57 0.23 0.05 0.65 0.19
HAPPI-2   1.00 0.42 0.40 0.06 0.41 0.50 0.01 0.02 0.77
HAPPI-1’    1.00 0.51 −0.12 −0.32 0.60 0.20 0.03 −0.11
HAPPI-1     1.00 −0.24 −0.60 0.50 −0.45 −0.21 −0.54
HPRD      1.00 0.25 0.00 0.26 −0.06 0.55
I2d       1.00 −0.60 −0.32 0.56 0.49
IntNetDB        1.00 0.00 −1.00 0.00
Wang         1.00 0.18 0.14
BioGRID          1.00 0.12
STRING           1.00
  1. The Spearman’s correlation coefficient is calculated by comparing the rankings of network degrees of connectivity among top-100 highly connected HAPPI-2 human proteins in each pair of databases under comparison. HAPPI-2’ and HAPPI-1’ refers to the medium- to ultrahigh-confidence subsets of the HAPPI-2 and HAPPI-1 database respectively. The pairs of databases with high (>0.25) correlation coefficients are bolded