Fig. 2From: Comparative genomics of canine hemoglobin genes reveals primacy of beta subunit delta in adult carnivoresEvidence of evolutionary selection spanning the beta globin locus in the Bernese Mountain Dog. There are two types of evidence that indicate that there has been “evolutionary” selection under domestication in this locus. The D i statistic for population differentiation shows the strongest signal in the genome of the Bernese Mountain Dog is in this region (marked in dark blue, with a second D i segment abutting it shown in light blue) [4]. We used that same data of Vaysse et al. to conduct direct phasing of haplotypes anchored in the SNPs nearest the beta globin locus (black bars show phased haplotype segments; arrow shows one of two nearby SNPs that show the same haplotype pattern). No other breed showed a large phased haplotype at this locus. One phased haplotype block overlaps the top D i region and contains the full beta globin locus (transcribed right to left here). Almost all the other genes in that segment appear as single ticks because they are intronless olfactory receptor genesBack to article page