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Fig. 5 | BMC Genomics

Fig. 5

From: Comparative genomics of canine hemoglobin genes reveals primacy of beta subunit delta in adult carnivores

Fig. 5

Promoter analysis of canine adult β globins. Canine HBD1, HBD2 and HBB are aligned with their carnivore (panda, ferret and cat) and human and horse orthologs. Sequences known to be bound by regulatory proteins are shown in yellow if they match the consensus and red if they are non-consensus. Dog HBD1 appears to carry the ancestral HBD promoter sequence, whereas both dog HBD2 and cat HBD (italics/underline) show evidence of gene conversion with acquisition of the full HBB promoter sequence. As a result, those genes now have consensus CACC boxes, which are known to be bound by erythroid Krüppel-like Factor (EKLF) to activate HBB expression

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