Fig. 3
From: Epithelial response to a high-protein diet in rat colon
a and b Relative expression values of a selection of significantly differentially expressed genes (q < 0.01) participating to the enriched pathways Glutathione-Mediated Detoxification (a) and DNA repair (b) in the colonocytes of rats fed a high-protein diet (HPD) compared to a normal-protein diet (NPD). The expression values were obtained by microarray experiment and normalized to the mean value in the NPD group. Gstm1, 3 and 5 (glutathione S-transferase mu 1, 3 and 5), Mgst1 (microsomal glutathione S-transferase 1), Gstt1 (glutathione S-transferase theta 1), Gsto1 (glutathione S-transferase omega 1), Nhej1 (non-homologous end-joining factor 1), Xab2 (XPA Binding Protein 2), Ddb1 (damage-specific DNA binding protein 1), Ogg1 (8-oxoguanine DNA glycosylase), Ung (uracil DNA glycosylase). c - DNA damages in colonocytes of rats fed an HPD or an NPD were assessed with the comet assay. The percentage of DNA in the tail of the comet is proportional to the amount of DNA damages in the cells. Mean values were compared with a t test. a-c Data presented are means +/- S.E.M