Fig. 2
From: De novo mutational profile in RB1 clarified using a mutation rate modeling algorithm
Overall and exon specific pathogenicity in nonsense mutations. a Comparison of the overall observed number of mutations to the simulated frequency of nonsense mutations in both RB and ExAC datasets. b Comparison of the observed number of mutations to the simulated frequency of nonsense mutations in RB, across exons 2 to 27. The asterisk (*) denotes that the observed number falls outside the 99% confidence interval (i.e., P < 0.01). CI: Confidence Interval